1 Result for "

Gomisin M 2

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Gomisin M 2" in MCE Product Catalog:

Gomisin M2
Gomisin M2
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Cat. No.: HY-N3963
CAS No.: 82425-45-4
Synonyms: (+)-Gomisin M2
Category:  

Neurological Disease Lignans Plants Infection Monophenols Phenols Phenylpropanoids Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.

Target:  

STAT NF-κB p38 MAPK IKK Apoptosis Wnt β-catenin DNA/RNA Synthesis

Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra chinensis with oral availability. Gomisin M2 inhibits STAT1 phosphorylation as well as NF-κB p65 phosphorylation and nuclear translocation. Gomisin M2 reduces inflammatory cell infiltration, cytokine and chemokine expression, and serum IgE and IgG2a levels. Gomisin M2 inhibits MAPK phosphorylation, IκBα degradation, and NF-κB nuclear translocation in keratinocytes. Gomisin M2 induces apoptosis, mitochondrial membrane potential disruption, and cytochrome c release, and inhibits DNA synthesis and mammosphere formation through downregulation of Wnt/β-catenin. Gomisin M2 can be used for research on atopic dermatitis, psoriasis, breast cancer, liver injury, and multidrug-resistant mammary adenocarcinoma .
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