2. Search Result
Search Result
Results for "

Gynostemma pentaphyllum

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

15

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1990
    Gypenoside XLIX
    2 Publications Verification

    		 PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a Ka value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .
    Gypenoside XLIX
  • HY-N8211
    Gypenoside L
    4 Publications Verification

    		 p38 MAPK ERK NF-κB Inflammation/Immunology Cancer
    Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .
    Gypenoside L
  • HY-N2440
    Gypenoside A
    1 Publications Verification

    		 Interleukin Related Reactive Oxygen Species (ROS) AMPK FOXO COX Apoptosis Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    Gypenoside A is an orally active triterpenoid compound that can be isolated from Gynostemma pentaphyllum. Gypenoside A has anti-inflammatory and antioxidant activities. Gypenoside A also has a certain protective effect on cardiomyocytes and can inhibit apoptosis. Gypenoside A can be used in the research of cardiovascular diseases and inflammation-related diseases .
    Gypenoside A
  • HY-16942
    Damulin B
    1 Publications Verification

    		 Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family CDK MMP Interleukin Related MDM-2/p53 Metabolic Disease Inflammation/Immunology Cancer
    Damulin B is a dammarane-type saponin found in Gynostemma pentaphyllum. Damulin B can inhibit cancer cell apoptosis, decrease mitochondrial membrane potential, inhibit ROS production and cause G0/G1 phase arrest. Damulin B can prevent Cisplatin (HY-17394)-induced acute kidney injury and induce hair growth. Damulin B shows anti-inflammation anti-diabetic and anti-obesity effect. Damulin B can be used for the researches of cancer, inflammation, metabolic disease, such as lung cancer, osteoarthritis and diabetes .
    Damulin B
  • HY-N6881
    Gypenoside XIII
    1 Publications Verification

    		 Others Cardiovascular Disease
    Gypenoside XIII is belonging to the gypenosides. Gypenosides, extracted from Gynostemma pentaphyllum, have various pharmacological properties and protect against cardiovascular diseases, especially atherosclerosis .
    Gypenoside XIII
  • HY-N7678
    Gypenoside LXXV
    1 Publications Verification

    		 Others Cancer
    Gypenoside LXXV, isolated from Gynostemma pentaphyllum, is one of the deglycosylated shapes of ginsenoside Rb1. Gypenoside LXXV significantly reduces cancer cell viability and displays an anti-cancer effect .
    Gypenoside LXXV
  • HY-N12327
    Ombuin-3-O-glucoside

    		Others Others
    Ombuin-3-O-glucoside is a flavonoid glycoside derived from Gynostemma pentaphyllum. Ombuin-3-O-glucoside has antioxidant activity .
    Ombuin-3-O-glucoside
  • HY-N3983
    Gynosaponin I

    		Others Others
    Gynosaponin I (compound 1) is a natural product that can be found in Gynostemma pentaphyllum .
    Gynosaponin I
  • HY-N17991
    Gypenoside XCI

    		Others
    Gypenoside XCI is a glycoside found in Gynostemma pentaphyllum .
    Gypenoside XCI
  • HY-N17994
    GypenosideZ-2

    		Drug Derivative Others
    GypenosideZ-2 is a dammarane-type triterpene saponin found in the aerial parts of Gynostemma pentaphyllum (Thunb.) Makino .
    GypenosideZ-2
  • HY-N18048
    Gypenoside CII

    		Sirtuin Others
    Gypenoside CII is a dammarane-type triterpene saponin that can be isolated from Gynostemma pentaphyllum. Gypenoside CII exerts no significant activating effect on recombinant human Sirt1, while its congeners are potent Sirt1 agonists .
    Gypenoside CII
  • HY-N17992
    Gypenoside UL5

    		Others Metabolic Disease Inflammation/Immunology
    Gypenoside UL5 (Compound UL5) is a dammarane-type triterpene saponin found in Gynostemma pentaphyllum. Gypenoside UL5 shows liver injury-inhibiting, anti-inflammatory and antioxidant properties. Gypenoside UL5 can be used for the research of hepatitis, fatty liver, and liver fibrosis .
    Gypenoside UL5
  • HY-N17993
    GypenosideZ-1

    		Others Others
    GypenosideZ-1 is a triterpenoid saponin found in Gynostemma pentaphyllum .
    GypenosideZ-1
  • HY-N18005
    Gypenoside LXIX

    		Others Others
    Gypenoside LXIX (Compound 4) is a glycoside found in the aerial parts of Gynostemma pentaphyllum .
    Gypenoside LXIX
  • HY-N18006
    Otophylloside C

    		Others Others
    Otophylloside C is a C21 steroidal glycoside compound found in the root of Gynostemma pentaphyllum .
    Otophylloside C

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: