2 Results for "

HIV-1 TAT protein domain

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "HIV-1 TAT protein domain" in MCE Product Catalog:

2
TAT-GluA2 3Y
TAT-GluA2 3Y
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2 Cited Publications
Cat. No.: HY-P2259
CAS No.: 1404188-93-7
Target:  

iGluR HIV Integrase Adenosine Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease

TAT-GluA2 3Y is a blood-brain barrier-permeable AMPA receptor inhibitory peptide that crosses cell membranes via the HIV-1 TAT protein domain. TAT-GluA2 3Y blocks the endocytosis of AMPA receptors, including the internalization of GluA1/GluA2 subunits, by disrupting interactions with the AP2, Brag2 and Syt3-GluA2 complexes, while also inhibiting long-term depression. TAT-GluA2 3Y blocks hypoxia-mediated AMPAR internalization, alleviates A1R-induced persistent synaptic inhibition, and reduces cerebral ischemic volume, neurological deficits and spatial memory deficits. TAT-GluA2 3Y blocks the effect of NLRP3 deficiency on fear generalization, inhibits amphetamine-induced behavioral/neurochemical sensitization, weakens the unconditioned stimulus-conditioned stimulus association of morphine, and promotes the extinction of morphine CPP. TAT-GluA2 3Y can be used in studies related to fear generalization, ischemic stroke, hypoxia, drug addiction and opioid addiction .
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Cys(Npys)-TAT (47-57)
Cys(Npys)-TAT (47-57)
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Cat. No.: HY-P4101
Target:  

HIV

Research Areas:  

Infection

Cys(Npys)-TAT (47-57) is a peptide fragment of TAT peptide and it is able to interact with plasmid DNA electrostatically. Cys(Npys)-TAT (47-57) is corresponding to the transduction domain of TAT with an activated cysteine residue C. TAT is a small nuclear transcriptional activator protein encoded by HIV-1 .
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