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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
140 Results for "
Hh
" in MedChemExpress (MCE) Product Catalog:
Products (140)
140 Results for "Hh" in MCE Product Catalog:
56
Category:
Alkaloids Veratrum nigrum Linn. Pyridine Alkaloids Plants Liliaceae Extract Endogenous metabolite Disease Research Fields Cancer Steroids
Target:
24
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
7
7 Cited Publications
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro .
5
5 Cited Publications
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells .
3
Ciliobrevin A (HPI-4) is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM .
3
3 Cited Publications
Cat. No.: HY-P70533
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF8; HBGF-8; Fibroblast Growth Factor 8; FGF-8; AIGF; Fibroblast Growth Factor; Androgen-Induced Growth Factor; KAL6; Fibroblast Growth Factor 8 (Androgen-Induced); Hh6; Heparin-Binding Growth Factor 8; FGF
Species:
Human
Mouse
Source:
E. coli
2
Research Areas:
Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .
2
Research Areas:
Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .
2
2
Target:
Research Areas:
CpG ODN 10101 sodium, a synthetic oligodeoxynucleotide (ODN), is a toll-like receptor 9 (TLR9) agonist. CpG ODN 10101 sodium is a potent inducer of cytokine/chemokine expression ex vivo when used in combination with HH2(VQLRIRVAVIRA-NH2). CpG ODN 10101 sodium induces IFN- secretion from dendritic cells (DCs) and stimulates B-cells.CpG ODN 10101 sodium has antiviral and immunomodulatory properties that can influence chronic infection with HCV .
2
2 Cited Publications
Cat. No.: HY-N0247
CAS No.: 58558-08-0
Category:
Umbelliferae Extract Plants Disease Research Fields Saccharides Cancer Carphephorus corymbosus (Nutt.) Torr. & A.Gray Monosaccharides
Target:
1
Target:
Research Areas:
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM . Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure .
1
1
1
1 Cited Publications
Cat. No.: HY-P700060AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF17; FGF-17; Fibroblast Growth Factor 17; Hh20; FGF-13
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P70399
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2Hh; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71633
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2Hh; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73258
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2Hh; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Human
Source:
HEK293
Target:
Research Areas:
4-Methylhistamine hydrochloride is the dihydrochloride salt of 4-Methylhistamine (HY-W580721). 4-Methylhistamine hydrochloride is a potent and selective agonist of histamine 4 receptor (H4R) with a Ki of 50 nM. 4-Methylhistamine hydrochloride has a >100-fold selectivity for the hH4R over the other histamine receptor subtypes. 4-Methylhistamine hydrochloride can potently activate the hH4R (pEC50 = 7.4). 4-Methylhistamine hydrochloride can be used for the researches of cancer, inflammation and immunology, such as lung cancer and skin inflammation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
