1. Stem Cell/Wnt
  2. Hedgehog
  3. Hh-Ag1.5

Hh-Ag1.5 (Synonyms: SAg1.5)

Cat. No.: HY-124899
Handling Instructions

Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure.

For research use only. We do not sell to patients.

Hh-Ag1.5 Chemical Structure

Hh-Ag1.5 Chemical Structure

CAS No. : 612542-14-0

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM[1]. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure[2].

IC50 & Target

EC50: 1 nM (Hedgehog)[1]

In Vitro

HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from non-injured liver in vitro[2].
Hh-Ag1.5 competely binds to the Smo-containing membranes with the Ki value of 0.52 nM[3].
The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM[4].

Molecular Weight

526.04

Formula

C₂₈H₂₆ClF₂N₃OS

CAS No.

612542-14-0

SMILES

O=C(C(SC1=C(C=C2)F)=C(C1=C2F)Cl)N([[email protected]@H](CC3)CC[[email protected]]3NC)CC4=CC(C5=CC=NC=C5)=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Hh-Ag1.5SAg1.5HedgehogquiescenceliverstemfailureInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Hh-Ag1.5
Cat. No.:
HY-124899
Quantity:
MCE Japan Authorized Agent: