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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
IRE1/ERN1
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "IRE1/ERN1" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM) [1].
1
Cat. No.: HY-123996
CAS No.: 20041-64-9
Research Areas:
3-Ethoxy-5,6-dibromosalicylaldehyde is an IRE1/ERN1 inhibitor, with an IC50 of 0.12 μM, a Ki of 71-88 nM, and a Kd of 100 nM against the ribonuclease activity of hIRE1α, as well as an IC50 of 4.8 μM against yeast Ire1. It shows selectivity toward IRE1 ribonuclease. 3-Ethoxy-5,6-dibromosalicylaldehyde blocks the IRE1/ERN1-mediated unfolded protein response (UPR) signaling pathway, including XBP-1 mRNA splicing, induction of XBP1 target genes, and activation of MAPK8/9/10, but does not alter the phosphorylation level of IRE1α or the PERK/ATF6 pathway. 3-Ethoxy-5,6-dibromosalicylaldehyde inhibits chikungunya virus replication, induces growth arrest, apoptosis and clonogenic inhibition in pancreatic cancer cells, reduces FB1 (Fumonisin B1) (HY-N6719)-induced autophagy and cell death, regulates PGG-induced senescence and apoptosis, and alleviates Sorafenib (HY-10201)-induced vacuolization and damage in hepatic stellate cells. 3-Ethoxy-5,6-dibromosalicylaldehyde can be used in research related to chikungunya virus infection, pancreatic cancer, FB1-induced nephrotoxicity, liver cancer, breast cancer, lung cancer and liver fibrosis [1] .
Cat. No.: HY-P73858
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ERN1; IRE1-Alpha; Endoplasmic Reticulum To Nucleus Signaling 1; HIRE1p; IRE1; IRE1a; Serine/Threonine-Protein Kinase/Endoribonuclease IRE1; Endoplasmic Reticulum-To-Nucleus Signaling 1; IRE1P; Non-Specific Serine/Threonine Protein Kinase; Inositol-Requiri
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P80828A
Synonyms: ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; IRE1-alpha; IRE1a
Cat. No.: HY-P73256
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERN1; IRE1-Alpha; Endoplasmic Reticulum To Nucleus Signaling 1; HIRE1p; IRE1; IRE1a; Serine/Threonine-Protein Kinase/Endoribonuclease IRE1; Endoplasmic Reticulum-To-Nucleus Signaling 1; IRE1P; Non-Specific Serine/Threonine Protein Kinase; Inositol-Requiri
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
