2328097-41-0
Chemical Structure
IRE1α kinase-IN-1
- CAS No.: 2328097-41-0
- Formula:C26H26ClFN8
- Molecular Weight:504.99
IUPAC Name: 6-chloro-3-(6-fluoro-2-(phenylamino)-1H-benzo[d]imidazol-5-yl)-N-((1-methylpiperidin-4-yl)methyl)imidazo[1,2-b]pyridazin-8-amine
InChIKey: BPRAHARGXSNSSO-UHFFFAOYSA-N
SMILES: CN1CCC(CNC2=CC(Cl)=NN3C2=NC=C3C4=C(F)C=C5C(N=C(NC6=CC=CC=C6)N5)=C4)CC1
Biological Activity: IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM)[1].
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IRE1α kinase-IN-1 | 98.94% | IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM). | ||||||||||||||||||||
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Keywords
