2. MAPK/ERK Pathway
  3. MAP3K
  4. AZ-TAK1

AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines.

For research use only. We do not sell to patients.

AZ-TAK1 Chemical Structure

AZ-TAK1 Chemical Structure

CAS No. : 1413440-36-4

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AZ-TAK1 Related Antibodies

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Description

AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines[1].

In Vitro

AZ-TAK1 (0.1μM) induces apoptosis in 28%, 24%, and 74% of Mino, SP53, and Jeko cells, respectively[1].
AZ-TAK1 increases mitochondrial depolarization, indicated by a decrease in the red/green fluorescence intensity ratio[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZ-TAK1 Related Antibodies
Molecular Weight

477.53

Formula

C25H28FN7O2
CAS No.
SMILES

FC1=C(C2=CN=C3C=CC=NN32)N=C(NC4=CC(OCCN5CCC(CC5)O)=CC(CC)=C4)N=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZ-TAK1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ-TAK11413440-36-4MAP3KMAP kinase kinase kinase, MEKK, MAPKKKTHRβTAK1p38IκB-αmitochondrial depolarizationapoptosislymphomaInhibitorinhibitorinhibit

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HY-153320
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