1362 Results for "

IgG1/

" in MedChemExpress (MCE) Product Catalog:
Products (1362)

1362 Results for "IgG1/" in MCE Product Catalog:

66
Trastuzumab (anti-HER2)
Trastuzumab (anti-HER2)
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66 Publications Verification
Art. -Nr.: HY-P9907A
CAS. Nr.: 180288-69-1
Synonyms: Anti-Human HER2, Humanized Antibody (anti-HER2)

Target:  

ADC Antibodies EGFR

Forschungsgebiete:  

Cancer

Trastuzumab (anti-HER2) is a humanized IgG1 monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab (anti-HER2) has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.
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66
Trastuzumab
Trastuzumab
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66 Publications Verification
Art. -Nr.: HY-P9907
CAS. Nr.: 180288-69-1
Synonyms: Anti-Human HER2, Humanized Antibody

Target:  

Radionuclide-Drug Conjugates (RDCs) EGFR ADC Antibodies

Forschungsgebiete:  

Cancer

Trastuzumab is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab can be used for the research of HER2-positive metastatic breast cancer and gastric cancer [1] . (Note: The product specifications below only indicate the effective content of Trastuzumab. The component ratio of this product is Trastuzumab : excipients = 1:0.6-1:0.9.)
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55
Cetuximab
Cetuximab
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55 Cited Publications
Art. -Nr.: HY-P9905
CAS. Nr.: 205923-56-4
Synonyms: C225; IMC-C225
Target:  

Radionuclide-Drug Conjugates (RDCs) EGFR

Forschungsgebiete:  

Cancer

Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity [1].
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40
Atezolizumab
Atezolizumab
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40 Cited Publications
Art. -Nr.: HY-P9904
CAS. Nr.: 1380723-44-3
Synonyms: MPDL3280A; RG-7446; RO-5541267

Target:  

PD-1/PD-L1 Apoptosis Autophagy

Forschungsgebiete:  

Cancer

Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.
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27
Infliximab
Infliximab
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27 Cited Publications
Art. -Nr.: HY-P9970
CAS. Nr.: 170277-31-3
Synonyms: Avakine; CT-P13; SB2; TA-650

Target:  

TNF Receptor

Forschungsgebiete:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research [1] .
The component ratio of this product is Active ingredient : Excipients = 9 : 47.
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27
Infliximab (Anti-TNF-α)
Infliximab (Anti-TNF-α)
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27 Cited Publications
Art. -Nr.: HY-P9970A
Synonyms: Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)

Target:  

TNF Receptor

Forschungsgebiete:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research [1] .
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20
Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control
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20 Cited Publications
Art. -Nr.: HY-P99001

Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Inflammation/Immunology Cancer

Human IgG1 kappa, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1 kappa antibody [1].
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20
Adalimumab
Adalimumab
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20 Cited Publications
Art. -Nr.: HY-P9908
CAS. Nr.: 331731-18-1
Synonyms: Anti-Human TNF-alpha, Human Antibody; ABBV-3373 Antibody

Target:  

TNF Receptor Bacterial

Forschungsgebiete:  

Inflammation/Immunology Cancer

Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor α (TNF-α).
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11
Daratumumab
Daratumumab
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11 Cited Publications
Art. -Nr.: HY-P9915
CAS. Nr.: 945721-28-8
Synonyms: Anti-Human CD38, Human Antibody; HuMax-CD38; JNJ-54767414

Target:  

CD38 ADC Antibodies

Forschungsgebiete:  

Inflammation/Immunology Cancer

Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition [1] .
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11
Daratumumab (Anti-CD38)
Daratumumab (Anti-CD38)
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11 Cited Publications
Art. -Nr.: HY-P9915A
CAS. Nr.: 945721-28-8
Synonyms: Anti-Human CD38, Human Antibody (PBS)

Target:  

ADC Antibodies CD38

Forschungsgebiete:  

Cancer

Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition [1] .
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11
Avelumab
Avelumab
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11 Cited Publications
Art. -Nr.: HY-108730
CAS. Nr.: 1537032-82-8
Synonyms: Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Inflammation/Immunology Cancer

Avelumab (Anti-Human PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab can be used for the study of chordoma [1].
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11
Avelumab (anti-PD-L1)
Avelumab (anti-PD-L1)
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11 Cited Publications
Art. -Nr.: HY-108730A
CAS. Nr.: 1537032-82-8
Reinheit:  96.02%

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Inflammation/Immunology Cancer

Avelumab (anti-PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab (anti-PD-L1) enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab (anti-PD-L1) can be used for the study of chordoma [1].
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10
Pertuzumab
Pertuzumab
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10 Cited Publications
Art. -Nr.: HY-P9912
CAS. Nr.: 380610-27-5

Target:  

EGFR

Forschungsgebiete:  

Cancer

Pertuzumab, a humanized IgG1 monoclonal antibody, is a HER2 dimerization inhibitor for the treatment of metastatic HER2-positive breast cancer.
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9
Sacituzumab
Sacituzumab
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9 Cited Publications
Art. -Nr.: HY-P99045
CAS. Nr.: 1796566-95-4
Synonyms: HRS7; hRS7

Target:  

ADC Antibodies TROP2

Forschungsgebiete:  

Cancer

Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer [1] .
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8
Mouse IgG1 kappa, Isotype Control
Mouse IgG1 kappa, Isotype Control
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8 Cited Publications
Art. -Nr.: HY-P99977

Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Inflammation/Immunology

Mouse IgG1 kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG1κ antibodies. Mouse IgG1 kappa, Isotype Control, by maintaining the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG1κ subtype primary antibody, eliminates false positive signals caused by non-specific binding in immunological experiments, thus playing a core role in verifying the specificity of the experiment. Mouse IgG1 kappa, Isotype Control can be applied to immunolocalization experiments in the field of cell biology, such as immunofluorescence staining and immunohistochemistry, assisting in research on protein subcellular localization and cell structure analysis, ensuring the reliability of experimental results [1] .
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6
Sotrovimab
Sotrovimab
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6 Cited Publications
Art. -Nr.: HY-P99340
CAS. Nr.: 2423014-07-5
Synonyms: VIR 7831; GSK-4182136

Target:  

SARS-CoV

Forschungsgebiete:  

Infection Cancer

Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease [1] .
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5
Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
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5 Cited Publications
Art. -Nr.: HY-P99137

Target:  

IFNAR

Forschungsgebiete:  

Inflammation/Immunology

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3) [1] .
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5
Ipilimumab
Ipilimumab
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5 Cited Publications
Art. -Nr.: HY-P9901
CAS. Nr.: 477202-00-9
Synonyms: MDX-010; BMS-734016

Target:  

CTLA-4

Forschungsgebiete:  

Cancer

Ipilimumab is a fully human monoclonal antibody IgG1κ that blocks the inhibitory receptor cytotoxic T lymphocyte antigen 4 (CTLA-4) on T cells. Ipilimumab can be used in unresectable or metastatic melanoma (MM) studies [1].
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5
Belimumab
Belimumab
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5 Cited Publications
Art. -Nr.: HY-P9952
CAS. Nr.: 356547-88-1
Synonyms: LymphoStat B

Target:  

TNF Receptor CD20

Forschungsgebiete:  

Cardiovascular Disease Inflammation/Immunology

Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research [1] . The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.
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4
Ipafricept
Ipafricept
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4 Cited Publications
Art. -Nr.: HY-P99667
CAS. Nr.: 1391727-24-4
Synonyms: OMP-54F28; FZD8-Fc

Target:  

Wnt

Forschungsgebiete:  

Cancer

Ipafricept (OMP-54F28; FZD8-Fc) is a first class recombinant fusion protein with the extracellular part of the human frizzled-8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands, which blocks Wnt signaling. Ipafricept reduces tumor growth and results in a decrease in both liver and lung metastases combined with Gemcitabine (HY-17026) in pancreatic cancer mouse models. Ipafricept shows solid tumor inhibition activity with well tolerance, such as desmoid tumor, germ cell cancer, ovarian cancer [1] .
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