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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
Inositol trisphosphate
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "Inositol trisphosphate" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: (-)-Xestospongin C
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2
2 Cited Publications
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GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb) with an IC50 of 9 nM. GNF362 also inhibits Itpka and Itpkc with IC50 values of 20 nM and 19 nM, respectively. Inositol trisphosphate 3’ kinase B (Itpkb) is a Ca 2+-dependent kinase, which phosphorylates the 3’ position of Ins (1,4,5) P3 to generate inositol 1,3,4,5-tetrakisphosphate [Ins (1,3,4,5) P4] .
1
1 Cited Publications
Synonyms: Inositol 1,4,5-trisphosphate trisodium; Ins(1,4,5)-P3 trisodium
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D-myo-Inositol-1,4,5-triphosphate sodium salt is the trisodium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.
1
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BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC50 value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer .
1
1 Cited Publications
Cat. No.: HY-103642
CAS No.: 103476-24-0
Synonyms: Inositol 1,4,5-trisphosphate hexapotassium salt; Ins(1,4,5)-P3 hexapotassium salt
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D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is the hexapotassium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.
1
1 Cited Publications
Synonyms: Inositol 1,4,5-trisphosphate tripotassium; Ins(1,4,5)-P3 tripotassium
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D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca 2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) .
Cat. No.: HY-142117
CAS No.: 149091-92-9
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Adenophostin A is an IP3 receptor (inositol 1,4,5-trisphosphate receptors) modulator and Ca 2+ releaser, with an IC50 of 1.3 nM, an EC50 of 1.4 nM, and a Ki of 0.18 nM in rats, and an IC50 of 0.95 nM in humans. Adenophostin A activates IP3 receptors, stimulates Ca 2+ release from intracellular stores and microsomes, inhibits the binding of [ 3H]IP3 to plasma membrane receptors, and activates chloride channels. Adenophostin A resists phosphorylation and dephosphorylation by IP3 metabolic enzymes to maintain its activity, and increases cytoplasmic [Ca 2+] levels via calcium mobilization from the endoplasmic reticulum of vascular smooth muscle cells. Adenophostin A is applicable to research related to hemorrhagic shock .
Cat. No.: HY-114457
CAS No.: 245126-95-8
Synonyms: L-alpha-PhosphatidylInositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2
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Human Gut Microbiota Metabolites Other Diseases Lipids Endogenous metabolite Disease Research Fields
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Cat. No.: HY-P1341
CAS No.: 343268-91-7
Synonyms: Orexin A (17-33) (human, mouse, rat, bovine)
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Synonyms: TO 188; Tazalest; Tazanol
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Tazanolast (TO 188) is an orally active selective mast cell stabilizer. Tazanolast prevents the elevation of intracellular calcium concentration, inhibits calcium uptake and Protein kinase C translocation, without directly inhibiting phospholipase C. Tazanolast inhibits ozone-induced airway hyperresponsiveness to Methacholine in guinea pigs, as well as passive cutaneous anaphylaxis, Schultz-Dale reaction, experimental asthma, passive cutaneous anaphylaxis in rats, and increased cutaneous vascular permeability in rats. Tazanolast does not alter airway responsiveness in sham-exposed guinea pigs, cell distribution in bronchoalveolar lavage fluid after ozone exposure, type II-IV allergic reactions, or histamine release from atopic leukocytes. Tazanolast can be used in research related to allergic diseases .
Cat. No.: HY-W795960
CAS No.: 108340-81-4
Cat. No.: HY-120985
CAS No.: 123000-02-2
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Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
Cat. No.: HY-157652
CAS No.: 799268-60-3
Synonyms: 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-Inositol-3′,4′,5′-trisphosphate) ammonium
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18:0-20:4 PI(3,4,5)P3 (1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium)) is a kind of biochemical reagent.
Cat. No.: HY-W403046A
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D-myo-Inositol-4-phosphate monoammonium is a metabolite of D-myo-Inositol 1,4,5-trisphosphate. D-myo-Inositol 1,4,5-trisphosphate, a second messenger, elicits Ca 2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) .
Cat. No.: HY-P5866
CAS No.: 120928-88-3
Synonyms: Manse-AT
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Cat. No.: HY-157715
CAS No.: 852043-38-0
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1,2-Dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) ammonium is a membrane-bound signaling molecule with activities that regulate cell growth, metabolism, proliferation, and survival. 1,2-Dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) ammonium plays an important role in cell physiology and participates in multiple signal transduction pathways. 1,2-Dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) ammonium has a profound effect on intracellular signaling.
Cat. No.: HY-172803
CAS No.: 2723569-00-2
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Ferroptosis inducer-7 is an orally active and selective ferroptosis inducer via inositol 1,4,5-trisphosphate receptor (IP3R)/calcium release-activated calcium channel protein (ORAI). Ferroptosis inducer-7 exhibits a notable effect in alleviating anemia symptoms, suppressing bone marrow CTLs activation, and improving hematopoietic function in immune-mediated bone marrow failure. Ferroptosis inducer-7 can be studied in research for aplastic anemia .
Cat. No.: HY-W790474
CAS No.: 93133-76-7
Cat. No.: HY-P70834
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: INPP5A; InsP3 5-Phosphatase; Inositol Polyphosphate-5-Phosphatase A; Type I Inositol-1,4,5-trisphosphate 5-Phosphatase; 5PTASE; Type I Inositol-1,4,5-trisphosphate 5-Phophatase; Type I Inositol 1,4,5-trisphosphate 5-Phosphatase; Inositol Polyphosphate 5-P
Species:
Human
Source:
HEK293
Cat. No.: HY-P704115
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITPRIPL1; Inositol 1,4,5-trisphosphate Receptor-Interacting Protein-Like 1; Prev. KIAA1754L; Inositol 1,4,5-Triphosphate Receptor Interacting Protein-Like 1; D1B; Inositol 1,4,5-Triphosphate Receptor-Interacting Protein-Like 1; Inositol 1,4,5-Trisphosphat
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
