175 Results for "

Iridoids

" in MedChemExpress (MCE) Product Catalog:
Products (175)

175 Results for "Iridoids" in MCE Product Catalog:

20
Geniposide
Geniposide
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20 Publications Verification
Cat. No.: HY-N0009
CAS No.: 24512-63-8
Category:  

Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis

Target:  

Amyloid-β Influenza Virus

Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
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13
Catalpol
Catalpol
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13 Cited Publications
Cat. No.: HY-N0820
CAS No.: 2415-24-9
Synonyms: Catalpinoside
Category:  

Neurological Disease Anti-aging Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Disease Research Fields Inflammation/Immunology Cancer

Target:  

HBV

Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .
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11
Aucubin
Aucubin
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11 Cited Publications
Cat. No.: HY-N0664
CAS No.: 479-98-1
Category:  

Infection Eucommia ulmoides Oliver Neurological Disease Iridoids Terpenoids Eucommiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial

Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .
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7
Loganin
Loganin
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7 Cited Publications
Cat. No.: HY-N0512
CAS No.: 18524-94-2
Synonyms: Loganoside
Category:  

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Plants Disease Research Fields Cancer

Target:  

Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related

Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .
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7
Cornuside
Cornuside
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7 Cited Publications
Cat. No.: HY-N0631
CAS No.: 131189-57-6
Category:  

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX

Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .
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4
Gentiopicroside
Gentiopicroside
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4 Cited Publications
Cat. No.: HY-N0494
CAS No.: 20831-76-9
Synonyms: Gentiopicrin
Category:  

Gentiana scabra Bunge Iridoids Terpenoids Gentianaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Cytochrome P450 HCV

Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.
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4
Sweroside
Sweroside
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4 Cited Publications
Cat. No.: HY-N0806
CAS No.: 14215-86-2
Category:  

Monophenols Labiatae Lespedeza tomentosa (Thunb.) Siebold ex Maxim. Metabolic Disease Phenols Plants Disease Research Fields

Target:  

Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP

Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .
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3
Ajugol
Ajugol
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3 Cited Publications
Cat. No.: HY-N0914
CAS No.: 52949-83-4
Category:  

Erythrophleum fordii Oliv. Iridoids Labiatae Terpenoids Other Diseases Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields

Target:  

Parasite Autophagy Interleukin Related Reactive Oxygen Species (ROS) mTOR

Ajugol is an orally active iridoid glycoside found in the traditional Chinese medicine Leonurus japonicus. Ajugol is an autophagy activator. Ajugol activates TFEB-mediated autophagy and lysosomal biogenesis. Ajugol also has anti-inflammatory effects. Ajugol has great potential in the research of asthma, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis .
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3
Asperuloside
Asperuloside
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3 Cited Publications
Cat. No.: HY-N1382
CAS No.: 14259-45-1
Category:  

Iridoids Terpenoids Rubiaceae Plants Disease Research Fields Inflammation/Immunology Hedyotis diffusa Willd.

Target:  

NO Synthase

Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .
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3
Monotropein
Monotropein
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3 Cited Publications
Cat. No.: HY-N0648
CAS No.: 5945-50-6
Category:  

Iridoids Pyrola calliantha H. Andr. Terpenoids Pyrolaceae Rubiaceae Plants Morinda officinalis How Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Apoptosis

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury .
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2
Shanziside
Shanziside
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2 Cited Publications
Cat. No.: HY-N4092
CAS No.: 29836-27-9
Category:  

Iridoids Labiatae Terpenoids Phaseolus lunatus L. Other Diseases Plants Disease Research Fields

Target:  

Others

Shanziside is a iridoid glucoside isolated from Phlomis tuberosa L .
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2
Genipin 1-β-D-gentiobioside
Genipin 1-β-D-gentiobioside
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2 Cited Publications
Cat. No.: HY-N2094
CAS No.: 29307-60-6
Synonyms: Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside
Category:  

Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis Disease Research Fields Inflammation/Immunology

Target:  

Others

Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.
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1
8-Epiloganic acid
8-Epiloganic acid
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1 Cited Publications
Cat. No.: HY-N8314
CAS No.: 82509-41-9
Category:  

other families Iridoids Terpenoids Other Diseases Plants Disease Research Fields

Target:  

Others

8-Epiloganic acid, an iridoid glucoside, can be found in Linaria cymbalaria (Scrophulariaceae) .
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1
Picroside III
Picroside III
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1 Cited Publications
Cat. No.: HY-N0409
CAS No.: 64461-95-6
Category:  

Monophenols Iridoids Terpenoids Scrophulariaceae Phenols Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields Inflammation/Immunology

Target:  

Others

Picroside III is an iridoid glycoside isolated from Picrorhiza scrophulariiflora (PS), a traditional Chinese medicine .
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1
Secoxyloganin
Secoxyloganin
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1 Cited Publications
Cat. No.: HY-N3009
CAS No.: 58822-47-2
Category:  

Cardiovascular Disease Caprifoliaceae Iridoids Lonicera japonica Thunb. Terpenoids Plants Disease Research Fields

Target:  

Drug Derivative Apoptosis Bcl-2 Family

Secoxyloganin is an orally effective iridoid derivative. Secoxyloganin can be isolated from the flower buds of L. japonica. Secoxyloganin induces Apoptosis by inhibiting the expression of Bcl-2. Secoxyloganin potently inhibits the proliferation of breast cancer cells, while exerting weak activity against normal mammary epithelial cells. Secoxyloganin inhibits the decrease in tail vein blood flow associated with allergic reactions .
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1
8-​O-​Acetylharpagide
8-​O-​Acetylharpagide
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1 Cited Publications
Cat. No.: HY-N0757
CAS No.: 6926-14-3
Category:  

Infection other families Iridoids Terpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Akt Bcl-2 Family Apoptosis Adrenergic Receptor

8-O-Acetylharpagide is an orally active iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor .
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4aα,7α,7aα-Nepetalactone
4aα,7α,7aα-Nepetalactone
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1 Cited Publications
Cat. No.: HY-129434A
CAS No.: 21651-62-7
Purity:  99.69%
Category:  

Infection other families Iridoids Terpenoids Plants Disease Research Fields

Target:  

Insecticide TRP Channel PKC CaMK

4aα,7α,7aα-Nepetalactone is an iridoid compound, a TRPA1 agonist, a repellent, and an attractant. 4aα,7α,7aα-Nepetalactone can be isolated from the oil of N. crispa. 4aα,7α,7aα-Nepetalactone induces repellent responses in three sap-sucking pests (Chinese psyllid, Asian citrus psyllid, and western flower thrips) via PKCα. Nepetalactone attracts two predatory lady beetles (Harmonia axyridis and Propylea japonica) through CaMKII. 4aα,7α,7aα-Nepetalactone causes mortality in Pogonomyrmex sp. ants. 4aα,7α,7aα-Nepetalactone can be used in studies related to bacterial infections and mandibulate pest infestations .
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Secologanin
Secologanin
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Cat. No.: HY-125598
CAS No.: 19351-63-4
Purity:  90.1%
Category:  

Caprifoliaceae Iridoids Lonicera japonica Thunb. Terpenoids Other Diseases Plants Disease Research Fields

Target:  

Drug Intermediate

Secologanin is an iridoid monoterpenoid glucoside found in the leaves of Lonicera tatarica and a key precursor for thousands of natural monoterpenoid alkaloids .
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Hastatoside
Hastatoside
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Cat. No.: HY-N2015
CAS No.: 50816-24-5
Category:  

Iridoids Verbenaceae Terpenoids Verbena officinalis Linn. Plants

Target:  

Others

Hastatoside is an iridoid glycoside that is isolated from Verbena officinalis and has a role in promoting sleep .
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Methyl deacetylasperulosidate
Methyl deacetylasperulosidate
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Cat. No.: HY-N1503
CAS No.: 52613-28-2
Synonyms: 6α-Hydroxygeniposide; Deacetylasperulosidic acid methyl ester
Category:  

Iridoids Terpenoids Rubiaceae Metabolic Disease Plants Disease Research Fields Hedyotis diffusa Willd.

Target:  

Biochemical Assay Reagents

Methyl deacetylasperulosidate (6α-Hydroxygeniposide; Deacetylasperulosidic acid methyl ester) is an iridoid compound that acts as a laxative agent with blood glucose-lowering activity. It induces a laxative effect in mice and lowers blood glucose levels in normal mice .
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