58822-47-2
Chemical Structure
Secoxyloganin
- CAS No.: 58822-47-2
- Formula:C17H24O11
- Molecular Weight:404.37
IUPAC Name: 2-((2S,3R,4S)-5-(methoxycarbonyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-vinyl-3,4-dihydro-2H-pyran-4-yl)acetic acid
InChIKey: MQLSOVRLZHTATK-PEYNGXJCSA-N
SMILES: C=C[C@@H]1[C@@H](C(C(OC)=O)=CO[C@@]1([H])O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)CC(O)=O
Biological Activity: Secoxyloganin is an orally effective iridoid derivative. Secoxyloganin can be isolated from the flower buds of L. japonica. Secoxyloganin induces Apoptosis by inhibiting the expression of Bcl-2. Secoxyloganin potently inhibits the proliferation of breast cancer cells, while exerting weak activity against normal mammary epithelial cells. Secoxyloganin inhibits the decrease in tail vein blood flow associated with allergic reactions[1][2].
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Secoxyloganin | 99.33% | Secoxyloganin is an orally effective iridoid derivative. Secoxyloganin can be isolated from the flower buds of L. japonica. Secoxyloganin induces Apoptosis by inhibiting the expression of Bcl-2. Secoxyloganin potently inhibits the proliferation of breast cancer cells, while exerting weak activity against normal mammary epithelial cells. Secoxyloganin inhibits the decrease in tail vein blood flow associated with allergic reactions. | ||||||||||||||||||||
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Secoxyloganin (Standard) | ≥98% | Secoxyloganin (Standard) is the analytical standard of Secoxyloganin. This product is intended for research and analytical applications. Secoxyloganin, isolated from Lonicera japonica Thunb, inhibits the blood flow (BF) decrease. Secoxyloganin has allergy-preventive activity. | ||||||||||||||||||||
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Similarity Score 0.91
HY-N1277Dimethyl secologanoside -
Similarity Score 0.89
HY-N6876Secologanoside -
Similarity Score 0.89
HY-N17900Secologanoside 7-methyl ester -
Similarity Score 0.88
HY-125598Secologanin -
Similarity Score 0.83
HY-126407Secologanin dimethyl acetal -
Similarity Score 0.82
HY-121380Secologanate -
Similarity Score 0.80
HY-N13331Demethylsecologanol -
Similarity Score 0.77
HY-N9571Diderroside -
Similarity Score 0.73
HY-N8882Oleoside 11-methyl ester -
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References
- [1]. Ma J, et al. Secoxyloganin inhibits growth of breast cancer MDA-MB-231 cells via induction of apoptosis and cell cycle arrest[J]. All Life, 2024, 17(1): 2408433.
- [2]. Oku H, et al. Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica. Biol Pharm Bull. 2011;34(8):1330-1333. [Content Brief]
