Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
Losartan
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "Losartan" in MCE Product Catalog:
60
Target:
Research Areas:
Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
60
Target:
Research Areas:
Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
Synonyms: E-3174; EXP-3174
Target:
Research Areas:
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
Synonyms: Losartan Carboxaldehyde; DuP 167
Target:
Research Areas:
EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions .
Cat. No.: HY-17512AR
CAS No.: 124750-99-8
Synonyms: DuP-753 potassium (Standard)
Research Areas:
Losartan (potassium) (Standard) is the analytical standard of Losartan (potassium). This product is intended for research and analytical applications. Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
Cat. No.: HY-17512S
CAS No.: 1030937-27-9
Synonyms: DuP-753 d4
Synonyms: E-3174 d4; EXP-3174 d4
Cat. No.: HY-120979
CAS No.: 791122-48-0
Target:
Research Areas:
NO-Losartan A (compound 2a) displays vasorelaxing effects, due to the release of NO, and antagonized the vasocontractile effects of Angiotensin II (HY-13948), with potency values similar to that of Losartan (HY-17512) .
Cat. No.: HY-17512S3
CAS No.: 1030936-22-1
Synonyms: DuP-753-d2
Cat. No.: HY-105506
CAS No.: 114798-27-5
Target:
Research Areas:
EXP-7711 is a non peptide angiotensin II (Ang II) AT1 receptor antagonist. EXP-7711’s affinity for wild-type AT1 receptor (Ki =180 nM) is lower than peptide antagonists, but higher than losartan (Ki = 12 nM). EXP-7711 can be used for research on cardiovascular conditions .
Cat. No.: HY-114950R
CAS No.: 114798-36-6
Synonyms: Losartan Carboxaldehyde (Standard); DuP 167 (Standard)
Target:
Research Areas:
EXP3179 (Standard) is the analytical standard of EXP3179. This product is intended for research and analytical applications. EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions .
Cat. No.: HY-154788S
Cat. No.: HY-17512S1
CAS No.: 1189729-40-5
Cat. No.: HY-17512R
CAS No.: 114798-26-4
Synonyms: DuP-753 (Standard)
Research Areas:
Losartan (Standard) is the analytical standard of Losartan. This product is intended for research and analytical applications. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
Cat. No.: HY-12765S1
Cat. No.: HY-W724743
CAS No.: 727718-93-6
Target:
Research Areas:
Losartan azide is a click chemistry reagent containing an azide group and is a synthetic intermediate for the preparation of angiotensin AT1R-targeted renal PET imaging probe [18 F]fluoropyridine-losartan .
Cat. No.: HY-17512AS
Synonyms: DuP-753-d6 hydrochloride
Cat. No.: HY-17512S4
CAS No.: 1030937-18-8
Synonyms: DuP-753-d9
Cat. No.: HY-12765R
CAS No.: 124750-92-1
Synonyms: E-3174 (Standard); EXP-3174 (Standard)
Research Areas:
Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure [4].
Cat. No.: HY-143980S
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
