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Cat. No.: HY-114950R

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EXP3179 (Standard)

Name: EXP3179 (Standard)
Brand: MedChemExpress
SKU: HY-114950R
Availability: PreOrder

(Synonyms: Losartan Carboxaldehyde (Standard); DuP 167 (Standard))

EXP3179 (Standard) (Losartan Carboxaldehyde (Standard)) is the analytical standard of EXP3179 (HY-114950). This product is intended for research and analytical applications. EXP3179 is a metabolite of Losartan (HY-17512). EXP3179 binds to AT1R with an affinity of 20 nM and blocks ANGII-induced AT1R signaling, inhibiting ERK1/2 activation. EXP3179 reduces NADPH oxidase activity. EXP3179 inhibits Phenylephrine (HY-B0769)-induced aortic contraction through an endothelium-dependent, NO-dependent mechanism. EXP3179 dose-dependently inhibits type I collagen-induced platelet aggregation and activation through GPVI binding, reducing platelet adhesion to the injured site. EXP3179 lowers blood pressure in normotensive and spontaneously hypertensive rats and mice. EXP3179 can be used for research on type 2 diabetes, hypertensive heart disease, hypertension, thrombosis, and coronary artery disease.

For research use only. We do not sell to patients.

CAS No.: 114798-36-6
Formula: C₂₂H₂₁ClN₆O
Molecular Weight:420.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EXP3179 (Standard) Chemical Structure

CAS No.: 114798-36-6

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The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 114798-36-6
Molecular Weight 420.89
Formula C₂₂H₂₁ClN₆O
SMILES

[H]N1N=NN=C1C2=CC=CC=C2C3=CC=C(C=C3)CN4C(C([H])=O)=C(N=C4CCCC)Cl
Synonyms

Losartan Carboxaldehyde (Standard); DuP 167 (Standard)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Pershadsingh HA. New generation angiotensin II type 1 receptor antagonists that selectively modulate peroxisome proliferator‐activated receptor‐γ. Drug development research. 2006 Aug;67(8):687-97.

[2]. Moreno MU, et al. Association of phagocytic NADPH oxidase activity with hypertensive heart disease: a role for cardiotrophin-1?. Hypertension. 2014 Mar;63(3):468-74.

[3]. Sauge E, et al. Losartan metabolite EXP3179 is a unique blood pressure-lowering AT1R antagonist with direct, rapid endothelium-dependent vasoactive properties. Vascular pharmacology. 2022 Dec;147:107112.

[4]. Li R, et al. Blocking platelet glycoprotein VI (GPVI) as a promising antithrombotic treatment. Drug discovery today. 2025 Oct;30(10):104473.

[5]. Bene M, et al. LOSARTAN REJUVENATES SERUM AND HEART METABOLOME OF AGED MICE BY ANGIOTENSIN DEPENDENT AND INDEPENDENT MECHANISMS. Innovation in Aging. 2024 Dec 1;8(Supplement_1):1144-.

[6]. Schieffer MB, et al. Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease. Journal of the American College of Cardiology. 2004 Jul 21;44(2):362-8.

[7]. Kumra H, et al. Improving response of pancreatic cancer to losartan: Mechanistic insights and implications for personalized therapy[J]. Cancer Research, 2026, 86(7_Supplement): 1781-1781.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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