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MC3T3-E1 preosteoblastic cells

" in MedChemExpress (MCE) Product Catalog:
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5-Methoxytryptophol
5-Methoxytryptophol
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Cat. No.: HY-113440
CAS No.: 712-09-4
Purity:  99.95%
Category:  

Alkaloids Neurological Disease Endogenous metabolite Disease Research Fields Indole Alkaloids

Target:  

Melatonin Receptor ERK TNF Receptor Interleukin Related MMP Endogenous Metabolite

5-Methoxytryptophol is a 5-methoxyindole alcohol structurally homologous to Melatonin (HY-B0075). It is secreted by the mammalian pineal gland and exhibits an inverse circadian rhythm. 5-Methoxytryptophol regulates bone metabolism by activating the ERK1/2 pathway. It reduces the levels of pro-inflammatory cytokines TNF-α and IL-1β, as well as proteolytic enzymes MMP-1 and MMP-2, in serum and dental pulp tissues, thereby ameliorating acute pulpitis. 5-Methoxytryptophol induces rapid sleep in mice, while high doses cause respiratory depression and death. 5-Methoxytryptophol. 5-Methoxytryptophol can be used in studies related to acute pulpitis, hypnosis, and bone metabolism .
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