369 Results for "

N-methyl

" in MedChemExpress (MCE) Product Catalog:
Products (369)

369 Results for "N-methyl" in MCE Product Catalog:

31
31 Publications Verification
Cat. No.: HY-17551
CAS No.: 6384-92-5
Synonyms: N-methyl-D-aspartic acid
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
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15
15 Cited Publications
Cat. No.: HY-Y0966
CAS No.: 56-40-6
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine inhibits the membrane aggregation of NINJ1 and prevents plasma membrane rupture during cell death. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .
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10
10 Cited Publications
Cat. No.: HY-B0591
CAS No.: 19982-08-2
Target:  

iGluR

Research Areas:  

Neurological Disease

Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD) .
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9
9 Cited Publications
Cat. No.: HY-N0215
CAS No.: 63-91-2
Synonyms: (S)-2-Amino-3-phenylpropionic acid
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca + channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
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7
7 Cited Publications
Cat. No.: HY-N2311
CAS No.: 2552-55-8
Synonyms: (RS)-Ibotenic acid; DL-Ibotenic acid
Target:  

iGluR

Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
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7
7 Cited Publications
Cat. No.: HY-100807
CAS No.: 89-00-9
Purity:  99.85%
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis .
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7
7 Cited Publications
Cat. No.: HY-130592
CAS No.: 848035-21-2
Purity:  99.95%
Synonyms: C48/80 trihydrochloride
Target:  

Phospholipase

Research Areas:  

Neurological Disease

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
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6
6 Cited Publications
Cat. No.: HY-17387
CAS No.: 102518-79-6
Synonyms: Huperzine A
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .
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4
4 Cited Publications
Cat. No.: HY-100811
CAS No.: 18000-24-3
Purity:  99.86%
Synonyms: 7-CKA
Target:  

iGluR

Research Areas:  

Neurological Disease

7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery .
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4
4 Cited Publications
Cat. No.: HY-100811A
CAS No.: 1263094-00-3
Purity:  99.79%
Synonyms: 7-CKA sodium salt
Target:  

iGluR

Research Areas:  

Neurological Disease

7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery .
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3
3 Cited Publications
Cat. No.: HY-101037
CAS No.: 107-97-1
Purity:  ≥98.0%
Synonyms: N-methylglycine; Sarcosin
Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .
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3
3 Cited Publications
Cat. No.: HY-N2370
CAS No.: 30271-38-6
Category:  

Animals Steroids

Target:  

iGluR LXR

24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
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3
3 Cited Publications
Cat. No.: HY-100714
CAS No.: 76326-31-3
Purity:  ≥98.0%
Synonyms: 2-APV; DL-2-Amino-5-phosphonovaleric acid
Target:  

iGluR

DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina .
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3
3 Cited Publications
Cat. No.: HY-100714C
CAS No.: 1303993-72-7
Purity:  99.20%
Synonyms: 2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium
Target:  

iGluR

DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina .
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2
2 Cited Publications
Cat. No.: HY-B0184
CAS No.: 25451-15-4
Synonyms: W-554; ADD-03055
Target:  

iGluR

Research Areas:  

Neurological Disease

Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).
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2
2 Cited Publications
Cat. No.: HY-136299B
Synonyms: FUT-187 trifluoroacetate
Target:  

iGluR

Research Areas:  

Neurological Disease

Sepimostat (FUT-187) trifluoroacetate exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat trifluoroacetate inhibits the Ifenprodil binding with a Ki value of 27.7 μM .
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2
2 Cited Publications
Cat. No.: HY-136299
CAS No.: 103926-64-3
Purity:  98.00%
Synonyms: FUT-187 free base
Target:  

iGluR

Research Areas:  

Neurological Disease

Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7?μM .
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2
2 Cited Publications
Cat. No.: HY-100807S
CAS No.: 138946-42-6
Purity:  99.90%
Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
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2
2 Cited Publications
Cat. No.: HY-N0215S10
CAS No.: 439685-11-7
Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C9
L-Phenylalanine- 13C9 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
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1
1 Cited Publications
Cat. No.: HY-W089645
CAS No.: 24589-78-4
Synonyms: N-methyl-n-trimethylsilyltrifluoroacetamide
Research Areas:  

Cancer

2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (N-Methyl-n-trimethylsilyltrifluoroacetamide) is an ester product commonly used for silylation reactions in analyticalchemistry. 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide can be used in the derivatization step of metabolomics analysis with gas chromatography/mass spectrometry (GC/MS) or as a derivatization reagent in GC with flame ionization detection analysis. 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide can be used in research for studying Tamoxifen (HY-13757A) resistant breast cancer cells and other disease pathways .
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