2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide
Based on 1 publication(s) in Google Scholar
2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (N-Methyl-n-trimethylsilyltrifluoroacetamide) is an ester product commonly used for silylation reactions in analyticalchemistry. 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide can be used in the derivatization step of metabolomics analysis with gas chromatography/mass spectrometry (GC/MS) or as a derivatization reagent in GC with flame ionization detection analysis. 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide can be used in research for studying Tamoxifen (HY-13757A) resistant breast cancer cells and other disease pathways.
For research use only. We do not sell to patients.
- Purity : 98.79%
- CAS No.: 24589-78-4
- Formula: C6H12F3NOSi
- Molecular Weight:199.25
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-13756
Tacrolimus -
HY-W105426
3-(Trimethoxysilyl)propyl methacrylate -
HY-12041
SP600125 -
HY-P0206
Bradykinin -
HY-123798
N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane -
HY-D0175
3-Aminopropyltriethoxysilane -
HY-123798R
N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane (Standard) -
HY-Y1410
Triisopropylsilane, 98% -
HY-W036410
Aminopropyltrimethoxysilane -
HY-D0908
Ninhydrin -
HY-91054
Triethoxyoctylsilane
Publications Citing Use of MedChemExpress (MCE) 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide
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Biological Activity
Description
In Vitro
2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (Compound MSTFA) can be used to volatilze compounds to improve chromatographic peak shape and convert protic functional groups to the corresponding trimethylsilyl (TMS) derivative[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 24589-78-4
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Appearance Liquid (Density: 1.074 g/cm3)
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Molecular Weight 199.25
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Formula C6H12F3NOSi
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Color Colorless to light yellow
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SMILES
O=C(N(C)[Si](C)(C)C)C(F)(F)F
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Synonyms
N-Methyl-n-trimethylsilyltrifluoroacetamide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
Metabolic Imprint of Poliovirus on Glioblastoma Cells and Its Role in Virus Replication and Cytopathic Activity. [Abstract]2025 Jul 30;26(15):7346. PMID: 40806477
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (1003.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Handling Instructions (2659 KB)
References
[1]. Böröczky, K., et al., (2006). Cluster analysis as selection and dereplication tool for the identification of new natural compounds from large sample sets. Chemistry & biodiversity, 3(6), 622–634. [Content Brief]
[2]. Müller, C., et al., (2019). A gas chromatography-mass spectrometry-based whole-cell screening assay for target identification in distal cholesterol biosynthesis. Nature protocols, 14(8), 2546–2570. [Content Brief]
[3]. Mishra, A., et al., (2024). Comparative metabolomics of MCF-7 and MCF-7/TAMR identifies potential metabolic pathways in tamoxifen resistant breast cancer cells. American journal of translational research, 16(4), 1337–1352. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.0188 mL | 25.0941 mL | 50.1882 mL | 125.4705 mL |
| 5 mM | 1.0038 mL | 5.0188 mL | 10.0376 mL | 25.0941 mL | |
| 10 mM | 0.5019 mL | 2.5094 mL | 5.0188 mL | 12.5471 mL | |
| 15 mM | 0.3346 mL | 1.6729 mL | 3.3459 mL | 8.3647 mL | |
| 20 mM | 0.2509 mL | 1.2547 mL | 2.5094 mL | 6.2735 mL | |
| 25 mM | 0.2008 mL | 1.0038 mL | 2.0075 mL | 5.0188 mL | |
| 30 mM | 0.1673 mL | 0.8365 mL | 1.6729 mL | 4.1824 mL | |
| 40 mM | 0.1255 mL | 0.6274 mL | 1.2547 mL | 3.1368 mL | |
| 50 mM | 0.1004 mL | 0.5019 mL | 1.0038 mL | 2.5094 mL | |
| 60 mM | 0.0836 mL | 0.4182 mL | 0.8365 mL | 2.0912 mL | |
| 80 mM | 0.0627 mL | 0.3137 mL | 0.6274 mL | 1.5684 mL | |
| 100 mM | 0.0502 mL | 0.2509 mL | 0.5019 mL | 1.2547 mL |
2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide Related Classifications
HY-W089645 Related Classifications
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