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Na /Ca2 exchange current

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (3) Calmodulin (3) Na+/Ca2+ Exchanger (10) Sodium Channel (6) Isotope-Labeled Compounds (1) Potassium Channel (4) Reference Standards (3)
By Research Areas:	Cardiovascular Disease (10) Neurological Disease (7)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: Na+/Ca2+ Exchanger Calcium Channel CRAC Channel Sodium Channel NKCC SOS1 Na+/HCO3- Cotransporter CaSR Calmodulin Na+/K+ ATPase CaMK Na+/H+ Exchanger (NHE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1546A

Benzamil hydrochloride 1 Publications Verification Benzylamiloride hydrochloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca ²⁺-activated currents, with an IC₅₀ of 1.1 μM .

HY-128678

ORM-10103	Na+/Ca2+ Exchanger	Cardiovascular Disease
ORM-10103 is a specific inhibitor of the *Na+/Ca2+ exchanger* (NCX)*, which decreases the NCX current* with estimated IC₅₀s of 55 and 67 nM at -80 and at 20 mV, respectively .

HY-136182A

YM-244769	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice .

HY-A0236

Aprindine	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine is an Ib-class anti-arrhythmic agent. Aprindine mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-136182

YM-244769 dihydrochloride	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 dihydrochloride is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-A0236A

Aprindine hydrochloride	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-107659

YM-244769 hydrochloride	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 hydrochloride is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-B1546

Benzamil Benzylamiloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil (Benzylamiloride), an Amiloride analogue, is a *Na ⁺/Ca ²⁺* exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC)** blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca ²⁺-activated currents, with an IC₅₀ of 1.1 μM .

HY-B1546AR

Benzamil hydrochloride (Standard) Benzylamiloride hydrochloride (Standard)	Na+/Ca2+ Exchanger Sodium Channel Reference Standards	Neurological Disease
Benzamil (hydrochloride) (Standard) is the analytical standard of Benzamil (hydrochloride). This product is intended for research and analytical applications. Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM .

HY-W710915

Aprindine hydrochloride-d10	Isotope-Labeled Compounds Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride-d₁₀ is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-107659R

YM-244769 hydrochloride (Standard)	Reference Standards Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 hydrochloride (Standard) is the analytical standard of YM-244769 (hydrochloride) (HY-107659). This product is intended for research and analytical applications. YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-132227

Dichlorobenzamil hydrochloride 3',4'-Dichlorobenzamil hydrochloride; L-594881 hydrochloride	Na+/Ca2+ Exchanger	Others
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) hydrochloride is a Na ⁺-Ca ²⁺ Exchanger inhibitor. Dichlorobenzamil (hydrochloride) attenuates the Na ⁺-Ca ²⁺ exchanger-mediated inward current induced by activation of type I metabotropic glutamate receptors in second-order baroreceptor neurons of the rat nucleus tractus solitarius .

HY-182252

SAR296968	Na+/Ca2+ Exchanger	Cardiovascular Disease
SAR296968 is a Na ⁺/Ca ²⁺ exchanger (NCX) subtype inhibitor with an IC₅₀ value of 74 nM against hNCX1. SAR296968 inhibits both forward and reverse modes of NCX current. SAR296968 enhances cardiac contractility and stroke volume. SAR296968 exerts antiarrhythmic effects. SAR296968 is applicable to research related to heart failure .

HY-A0236AR

Aprindine hydrochloride (Standard)	Reference Standards Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine hydrochloride (Standard) is the analytical reference standard of Aprindine hydrochloride (HY-A0236A). This product is used for research and analytical applications. Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias.

Cat. No.	Product Name	Chemical Structure

HY-W710915

Aprindine hydrochloride-d10
Aprindine hydrochloride-d₁₀ is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

Aprindine hydrochloride-d10

Aprindine hydrochloride-d₁₀ is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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