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Cat. No.: HY-132227

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Dichlorobenzamil hydrochloride

Name: Dichlorobenzamil hydrochloride
Brand: MedChemExpress
SKU: HY-132227
Availability: PreOrder

(Synonyms: 3',4'-Dichlorobenzamil hydrochloride; L-594881 hydrochloride)

Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) hydrochloride is a Na⁺-Ca²⁺ Exchanger inhibitor. Dichlorobenzamil (hydrochloride) attenuates the Na⁺-Ca²⁺ exchanger-mediated inward current induced by activation of type I metabotropic glutamate receptors in second-order baroreceptor neurons of the rat nucleus tractus solitarius.

For research use only. We do not sell to patients.

CAS No.: 928621-15-2
Formula: C₁₃H₁₃Cl₄N₇O
Molecular Weight:425.10

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Please store the product under the recommended conditions in the Certificate of Analysis.

Dichlorobenzamil hydrochloride Chemical Structure

CAS No.: 928621-15-2

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Biological Activity
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Chemical Information
Protocols (1)
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Biological Activity

Description

In Vitro

Dichlorobenzamil hydrochloride (100 μM; 1 min) significantly attenuates the Group I mGluR agonist-induced inward current in anatomically identified second-order baroreceptor NTS neurons, reducing the current to 55.1 ± 8.6% of control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 928621-15-2
Molecular Weight 425.10
Formula C₁₃H₁₃Cl₄N₇O
SMILES

O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=C(C(Cl)=C2)Cl)=N.Cl
Synonyms

3',4'-Dichlorobenzamil hydrochloride; L-594881 hydrochloride
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sekizawa S, et al. Group I metabotropic glutamate receptors on second-order baroreceptor neurons are tonically activated and induce a Na+-Ca2+ exchange current. J Neurophysiol. 2006;95(2):882-892. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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