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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
674 Results for "
Opioids
" in MedChemExpress (MCE) Product Catalog:
Products (674)
674 Results for "Opioids" in MCE Product Catalog:
19
Category:
Neurological Disease Sinomenium acutum(Thunb．)Rehd．Et Wils． Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Disease Research Fields Inflammation/Immunology
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19
19 Publications Verification
別名: Cucoline hydrochloride
Category:
Neurological Disease Sinomenium acutum(Thunb．)Rehd．Et Wils． Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Disease Research Fields Inflammation/Immunology
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19
18
18 Cited Publications
製品番号: HY-B0193
CAS 番号: 19216-56-9
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15
15 Cited Publications
製品番号: HY-P0210
CAS 番号: 78123-71-4
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研究分野:
15
15 Cited Publications
製品番号: HY-P0210B
CAS 番号: 950492-85-0
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13
Target:
Loperamide (ADL 2-1294) is selective and orally active μ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2 (HY-101952)- and Cholera toxin (HY-P1446)-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea .
13
Target:
Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .
10
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Aticaprant (CERC-501) is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM.
8
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Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias .
8
8 Cited Publications
別名: nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride
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研究分野:
Norbinaltorphimine dihydrochloride (nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride) is a selective, long-acting competitive antagonist of the κ-opioid receptor. Norbinaltorphimine dihydrochloride blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. Norbinaltorphimine dihydrochloride suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. Norbinaltorphimine dihydrochloride is applicable to research related to neurological disorders such as pain .
8
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研究分野:
nor-Binaltorphimine (Norbinaltorphimine; NorBNI) is a selective, long-acting competitive antagonist of the κ-opioid receptor. nor-Binaltorphimine blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. nor-Binaltorphimine suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. nor-Binaltorphimine is applicable to research related to neurological disorders such as pain .
8
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研究分野:
Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias .
7
7 Cited Publications
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JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2 nM.
6
6 Cited Publications
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研究分野:
MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively . MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity .
5
5 Cited Publications
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PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM .
4
4 Cited Publications
製品番号: HY-P0073
CAS 番号: 58569-55-4
別名: Met-Enkephalin; Methionine enkephalin; Metenkefalin
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研究分野:
3
3 Cited Publications
製品番号: HY-P1334
CAS 番号: 88373-73-3
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研究分野:
3
3 Cited Publications
製品番号: HY-P1334A
CAS 番号: 172888-59-4
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3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
