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Orthopoxvirus

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75

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1

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GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13605
    Cytarabine
    Maximum Cited Publications
    95 Publications Verification

    Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus Infection Cancer
    Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
    Cytarabine
  • HY-B0313
    Hydroxyurea
    30+ Cited Publications

    Hydroxycarbamide

    		 DNA/RNA Synthesis Autophagy Apoptosis HIV Orthopoxvirus Cancer
    Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity.
    Hydroxyurea
  • HY-B0272
    Rifampicin
    40+ Cited Publications

    Rifampin; Rifamycin AMP

    		 Bacterial Influenza Virus Antibiotic Orthopoxvirus Infection Cancer
    Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity.
    Rifampicin
  • HY-B0434
    Ribavirin
    55+ Cited Publications

    Ribasphere

    		 HCV RSV Orthopoxvirus Antibiotic Infection Cancer
    Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
    Ribavirin
  • HY-13502
    Mitoxantrone
    45+ Cited Publications

    Mitozantrone; NSC 301739

    		 Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite Infection Cancer
    Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
    Mitoxantrone
  • HY-10442
    3-Deazaneplanocin A
    30+ Cited Publications

    DZNep; 3-Deazaneplanocin

    		 Histone Methyltransferase S-adenosylhomocysteine hydrolase (SAHH) Orthopoxvirus Infection Metabolic Disease Inflammation/Immunology Cancer
    3-Deazaneplanocin A (DZNep) is a potent histone methyltransferase EZH2 inhibitor . 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus activity .
    3-Deazaneplanocin A
  • HY-B0330
    Levofloxacin
    30+ Cited Publications

    (-)-Ofloxacin

    		 Topoisomerase DNA/RNA Synthesis Antibiotic Bacterial Orthopoxvirus Infection Cancer
    Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity .
    Levofloxacin
  • HY-N6733
    Aphidicolin
    10+ Cited Publications

    		 DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus Infection Inflammation/Immunology
    Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .
    Aphidicolin
  • HY-B0425
    Novobiocin
    10+ Cited Publications

    Albamycin; Cathomycin

    		 Antibiotic DNA/RNA Synthesis HSP Apoptosis Bacterial Orthopoxvirus Infection Cancer
    Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity .
    Novobiocin
  • HY-B0425A
    Novobiocin sodium
    10+ Cited Publications

    Albamycin sodium; Cathomycin sodium

    		 Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP Infection Cancer
    Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .
    Novobiocin sodium
  • HY-17438
    Cidofovir
    10+ Cited Publications

    GS 0504; HPMPC; (S)-HPMPC

    		 CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite Infection Cancer
    Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .
    Cidofovir
  • HY-B0307
    Idoxuridine
    5+ Cited Publications

    5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd

    		 DNA/RNA Synthesis Phosphatase Orthopoxvirus Infection Cancer
    Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
    Idoxuridine
  • HY-13502A
    Mitoxantrone dihydrochloride
    45+ Cited Publications

    Mitozantrone dihydrochloride; NSC 301739 dihydrochloride

    		 Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite Infection Cancer
    Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
    Mitoxantrone dihydrochloride
  • HY-A0061
    Trifluridine
    3 Publications Verification

    Trifluorothymidine; 5-Trifluorothymidine; TFT

    		 Thymidylate Synthase HSV Nucleoside Antimetabolite/Analog Orthopoxvirus DNA/RNA Synthesis Apoptosis Autophagy Cancer
    Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors .
    Trifluridine
  • HY-14805
    Tecovirimat
    1 Publications Verification

    ST-246

    		 Orthopoxvirus Arenavirus Infection
    Tecovirimat (ST-246) is an orally bioavailable and selective compound against orthopoxviruses including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC50 values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus .
    Tecovirimat
  • HY-B0402
    Amantadine
    5+ Cited Publications

    1-Adamantanamine; 1-Aminoadamantane

    		 Influenza Virus Orthopoxvirus SARS-CoV Apoptosis CDK Bcl-2 Family Infection Neurological Disease Cancer
    Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
    Amantadine
  • HY-N7452
    Coumermycin A1
    25+ Cited Publications

    		 JAK Bacterial Orthopoxvirus Metabolic Disease
    Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.
    Coumermycin A1
  • HY-12186
    3-Deazaneplanocin A hydrochloride
    30+ Cited Publications

    DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride

    		 Histone Methyltransferase S-adenosylhomocysteine hydrolase (SAHH) Orthopoxvirus Infection Inflammation/Immunology Cancer
    3-Deazaneplanocin A hydrochloride (DZNep hydrochloride) is a potent histone methyltransferase EZH2 inhibitor . 3-Deazaneplanocin A hydrochlorideis a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor . 3-Deazaneplanocin A hydrochloride also has anti-orthopoxvirus and anti-variola activities .
    3-Deazaneplanocin A hydrochloride
  • HY-118122
    Fialuridine

    FIAU; DRG-0098; NSC 678514

    		 HSV HBV DNA/RNA Synthesis Orthopoxvirus Nucleoside Antimetabolite/Analog Infection
    Fialuridine (FIAU), a nucleoside analog, is a HSV-1 and HSV-2 inhibitor with Kis of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC50 values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively .
    Fialuridine
  • HY-B0402A
    Amantadine hydrochloride
    5+ Cited Publications

    1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride

    		 Influenza Virus Orthopoxvirus SARS-CoV Apoptosis Bcl-2 Family CDK Infection Neurological Disease Cancer
    Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
    Amantadine hydrochloride
  • HY-B0330A
    Levofloxacin hydrate
    30+ Cited Publications

    Levofloxacin hemihydrate

    		 Bacterial Antibiotic Topoisomerase DNA/RNA Synthesis Orthopoxvirus Infection Cancer
    Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity .
    Levofloxacin hydrate
  • HY-B1516
    Alovudine
    3 Publications Verification

    3'-Fluoro-3'-deoxythymidine; 3′-Deoxy-3′-fluorothymidine; FLT

    		 DNA/RNA Synthesis Orthopoxvirus Infection Cancer
    Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity .
    Alovudine
  • HY-B1299A
    Cephalosporin C zinc salt
    1 Publications Verification

    		 Bacterial Orthopoxvirus Antibiotic Infection Inflammation/Immunology
    Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM . Cephalosporin C zinc salt also has moderate anti-orthopoxvirus activity .
    Cephalosporin C zinc salt
  • HY-124108
    Eicosatetraynoic acid

    ETYA

    		 COX Lipoxygenase Orthopoxvirus Potassium Channel DNA/RNA Synthesis Drug Derivative Infection Neurological Disease Inflammation/Immunology Cancer
    Eicosatetraynoic acid (ETYA) is a non-metabolizable analog of Arachidonic acid (HY-109590) and also an inhibitor of the lipoxygenase (LOX)/cyclooxygenase (COX) pathway (ID50 = 8 μM and 4 μM). Eicosatetraynoic acid acts as a suicide substrate to inhibit the production of inflammatory mediators such as leukotrienes and prostaglandins. Eicosatetraynoic acid acts directly on cell membranes and membrane proteins to exert a wide range of effects, including blocking potassium channels, increasing cell membrane fluidity, elevating intracellular calcium levels, inhibiting DNA synthesis in tumor cells, inducing differentiation of certain cells, and specifically inhibiting the assembly and replication of orthopoxviruses. Eicosatetraynoic acid alleviates acute lung injury induced by chemicals such as phosgene .
    Eicosatetraynoic acid
  • HY-B0272R
    Rifampicin (Standard)

    Rifampin (Standard); Rifamycin AMP (Standard)

    		 Reference Standards Bacterial Influenza Virus Antibiotic Orthopoxvirus Infection Cancer
    Rifampicin (Standard) is the analytical standard of Rifampicin. This product is intended for research and analytical applications. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity.
    Rifampicin (Standard)
  • HY-W291131
    Isatin-β-thiosemicarbazone

    IBT

    		 HSV Orthopoxvirus Infection
    Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits
    Isatin-β-thiosemicarbazone
  • HY-175636
    ITGB3-IN-1

    		Integrin Orthopoxvirus Potassium Channel Infection
    ITGB3-IN-1 is an orally active integrin subunit beta 3 ITGB3 inhibitor with a Kd of 7.26 μM. ITGB3-IN-1 exhibits potent anti-orthopoxvirus effects with an EC50 for vaccinia virus (VACV) of 1.82 μM. ITGB3-IN-1 inhibits hERG with an IC50 of 1.13 μM. ITGB3-IN-1 can be used for the study of orthopoxvirus .
    ITGB3-IN-1
  • HY-114570
    Tiazofurin
    1 Publications Verification

    NSC 286193; Riboxamide

    		 Nucleoside Antimetabolite/Analog Orthopoxvirus Infection Neurological Disease Cancer
    Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer .
    Tiazofurin
  • HY-B0402S1
    Amantadine-d6

    1-Adamantanamine-d6; 1-Aminoadamantane-d6

    		 Apoptosis CDK SARS-CoV Bcl-2 Family Influenza Virus Orthopoxvirus Cancer
    Amantadine-d6 is the deuterium labeled Amantadine . Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
    Amantadine-d6
  • HY-B0313R
    Hydroxyurea (Standard)

    Hydroxycarbamide (Standard)

    		 Reference Standards DNA/RNA Synthesis Autophagy Apoptosis HIV Orthopoxvirus Cancer
    Hydroxyurea (Standard) is the analytical standard of Hydroxyurea. This product is intended for research and analytical applications. Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity.
    Hydroxyurea (Standard)
  • HY-B0434R
    Ribavirin (Standard)

    Ribasphere (Standard)

    		 Reference Standards HCV RSV Orthopoxvirus Antibiotic Infection Cancer
    Ribavirin (Standard) is the analytical standard of Ribavirin. This product is intended for research and analytical applications. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
    Ribavirin (Standard)
  • HY-13605R
    Cytarabine (Standard)

    Cytosine β-D-arabinofuranoside (Standard); Cytosine Arabinoside (Standard); Ara-C (Standard)

    		 Reference Standards DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus Infection Cancer
    Cytarabine (Standard) is the analytical standard of Cytarabine. This product is intended for research and analytical applications. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
    Cytarabine (Standard)
  • HY-14805A
    Tecovirimat monohydrate
    1 Publications Verification

    ST-246 monohydrate

    		 Orthopoxvirus Arenavirus Infection
    Tecovirimat (ST-246) monohydrate is the monohydrate form of Tecovirimat (HY-14805). Tecovirimat monohydrate is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat monohydrate is evaluated against vaccinia, cowpox virus, ectromelia virus with EC50 values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat monohydrate targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat monohydrate exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat monohydrate could be used in the study for orthopoxvirus-induced diseases .
    Tecovirimat monohydrate
  • HY-B0330R
    Levofloxacin (Standard)
    30+ Cited Publications

    (-)-Ofloxacin (Standard)

    		 Antibiotic DNA/RNA Synthesis Orthopoxvirus Topoisomerase Bacterial Reference Standards Infection Cancer
    Levofloxacin (Standard) is the analytical standard of Levofloxacin. This product is intended for research and analytical applications. Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity .
    Levofloxacin (Standard)
  • HY-B0402B
    Amantadine sulfate

    1-Adamantanamine sulfate; 1-Aminoadamantane sulfate

    		 Influenza Virus Orthopoxvirus SARS-CoV Apoptosis CDK Bcl-2 Family Infection Neurological Disease Cancer
    Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
    Amantadine sulfate
  • HY-17438A
    Cidofovir dihydrate

    GS 0504 dihydrate; HPMPC dihydrate; (S)-HPMPC dihydrate

    		 CMV DNA/RNA Synthesis Orthopoxvirus Apoptosis Endogenous Metabolite Infection Cancer
    Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities .
    Cidofovir dihydrate
  • HY-147016
    NIOCH 14

    		Orthopoxvirus Infection
    NIOCH 14 is a antiviral agent and a pro-agent. NIOCH 14 has antiviral activity against orthopoxviruses. NIOCH 14 can significantly lower proportions of infected mice, and virus production levels in the lungs. NIOCH 14 can be used for researching anti-smallpox . NIOCH 14 shows anti-orthopoxvirus activity.
    NIOCH 14
  • HY-B0434G
    Ribavirin

    Ribasphere; ICN-1229

    		 Antibiotic RSV HCV Orthopoxvirus Infection
    Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
    Ribavirin
  • HY-14805S
    Tecovirimat-d4

    ST-246-d4

    		 Isotope-Labeled Compounds Orthopoxvirus Arenavirus Infection
    Tecovirimat-d4 (ST-246-d4) is a deuterium-labelled Tecovirimat (HY-14805). Tecovirimat is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC50 values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat could be used in the study for orthopoxvirus-induced diseases .
    Tecovirimat-d4
  • HY-B0402AR
    Amantadine hydrochloride (Standard)

    1-Adamantanamine hydrochloride (Standard); 1-Adamantylamine hydrochloride (Standard); 1-Aminoadamantane hydrochloride (Standard)

    		 Reference Standards Influenza Virus Orthopoxvirus SARS-CoV Apoptosis Bcl-2 Family CDK Infection Neurological Disease Cancer
    Amantadine (hydrochloride) (Standard) is the analytical standard of Amantadine (hydrochloride). This product is intended for research and analytical applications. Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
    Amantadine hydrochloride (Standard)
  • HY-B0402R1
    Amantadine in Methanol (Standard)

    1-Adamantanamine in Methanol (Standard); 1-Aminoadamantane in Methanol (Standard)

    		 Reference Standards Influenza Virus Orthopoxvirus SARS-CoV Apoptosis CDK Bcl-2 Family Infection Neurological Disease Cancer
    Amantadine in Methanol (Standard) is the solution of Amantadine (Standard). This product is intended for research and analytical applications. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research [4] .
    Amantadine in Methanol (Standard)
  • HY-147015
    HOE961

    		Orthopoxvirus Infection
    HOE961, the diacetate ester proagent of S2242, is active against respiratory cowpox virus infections, is orally active in infection models. Anti-orthopoxvirus activity .
    HOE961
  • HY-W698472
    Hydroxyurea-15N

    Hydroxycarbamide-15N

    		 Isotope-Labeled Compounds Apoptosis DNA/RNA Synthesis Autophagy HIV Orthopoxvirus Cancer
    Hydroxyurea- 15N (Hydroxycarbamide- 15N) is the 15N labeled Hydroxyurea (HY-B0313). Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity.
    Hydroxyurea-15N
  • HY-178449
    Orthopoxviruses-IN-1

    		Orthopoxvirus Infection
    Orthopoxviruses-IN-1 (Compound 4) is a potent p37 protein inhibitor (IC50= 0.017 µM against Vaccinia virus (VACV)). Orthopoxviruses-IN-1 is promising for research of orthopoxvirus-related diseases, including variola virus (smallpox) and monkeypox .
    Orthopoxviruses-IN-1
  • HY-14805R
    Tecovirimat (Standard)

    ST-246 (Standard)

    		 Reference Standards Arenavirus Orthopoxvirus Infection
    Tecovirimat (Standard) is the analytical standard of Tecovirimat. This product is intended for research and analytical applications. Tecovirimat(ST-246) is an orally bioavailable antipoxvirus compound; potent and selective active against multiple orthopoxviruses with EC50 about 10 nM. Tecovirimat could be used in the study for orthopoxvirus-induced diseases.
    Tecovirimat (Standard)
  • HY-B0434S1
    Ribavirin-15N, d2

    ICN-1229-15N, d2

    		 RSV Antibiotic Orthopoxvirus HCV Isotope-Labeled Compounds Infection Cancer
    Ribavirin- 15N, d2 is 15N and deuterated labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
    Ribavirin-15N, d2
  • HY-B0330C
    Levofloxacin sodium

    (-)-Ofloxacin sodium

    		 Antibiotic Orthopoxvirus Bacterial DNA/RNA Synthesis Topoisomerase Infection Inflammation/Immunology Cancer
    Levofloxacin ((-)-Ofloxacin) sodium is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin sodium inhibits the DNA gyrase and topoisomerase IV. Levofloxacin sodium can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin sodium shows anti-orthopoxvirus activity .
    Levofloxacin sodium
  • HY-B0272S3
    Rifampicin-d11

    Rifampin-d11; Rifamycin AMP-d11

    		 Isotope-Labeled Compounds Antibiotic Bacterial Influenza Virus Orthopoxvirus Others
    Rifampicin-d11 (Rifampin-d11; Rifamycin AMP-d11) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity .
    Rifampicin-d11
  • HY-A0061S
    Trifluridine-13C,15N2

    Trifluorothymidine-13C,15N2; 5-Trifluorothymidine-13C,15N2; TFT-13C,15N2

    		 Thymidylate Synthase Nucleoside Antimetabolite/Analog HSV Orthopoxvirus Cancer
    Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity .
    Trifluridine-13C,15N2
  • HY-B0330AR
    Levofloxacin hydrate (Standard)

    Levofloxacin hemihydrate (Standard)

    		 Reference Standards Bacterial Antibiotic Topoisomerase DNA/RNA Synthesis Orthopoxvirus Infection Cancer
    Levofloxacin (hydrate) (Standard) is the analytical standard of Levofloxacin (hydrate). This product is intended for research and analytical applications. Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity .
    Levofloxacin hydrate (Standard)

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