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PGP hydrate (Standard)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P-glycoprotein (22) Adrenergic Receptor (1) Akt (2) Antibiotic (5) Apoptosis (4) Autophagy (3) Bacterial (3) Bcl-2 Family (2) BCRP (5) Calcium Channel (3) Caspase (3) Cytochrome P450 (4) Dimethylargininase (DDAH) (1) Dopamine β-hydroxylase (1) Drug Metabolite (1) Endogenous Metabolite (3) Hedgehog (1) HIV (2) HIV Protease (2) IAP (1) iGluR (1) MMP (1) NF-κB (2) p38 MAPK (2) Parasite (2) PARP (1) PI3K (1) PPAR (1) Reference Standards (32) SARS-CoV (2) Survivin (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (5) Infection (7) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (1)

By Targets:

P-glycoprotein (22)

Adrenergic Receptor (1)

Akt (2)

Antibiotic (5)

Apoptosis (4)

Autophagy (3)

Bacterial (3)

Bcl-2 Family (2)

BCRP (5)

Calcium Channel (3)

Caspase (3)

Cytochrome P450 (4)

Dimethylargininase (DDAH) (1)

Dopamine β-hydroxylase (1)

Drug Metabolite (1)

Endogenous Metabolite (3)

Hedgehog (1)

HIV (2)

HIV Protease (2)

IAP (1)

iGluR (1)

MMP (1)

NF-κB (2)

p38 MAPK (2)

Parasite (2)

PARP (1)

PI3K (1)

PPAR (1)

Reference Standards (32)

SARS-CoV (2)

Survivin (1)

By Research Areas:

Cancer (22)

Cardiovascular Disease (5)

Infection (7)

Inflammation/Immunology (4)

Metabolic Disease (3)

Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Targets Recommended: P-glycoprotein CD44

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-50879R

Elacridar (Standard) GF120918 (Standard); GW0918 (Standard); GG918 (Standard); GW120918 (Standard)	P-glycoprotein BCRP Reference Standards	Cancer
Elacridar (Standard) is the analytical standard of Elacridar. This product is intended for research and analytical applications. Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer .

HY-A0064R

Verapamil hydrochloride (Standard) (±)-Verapamil hydrochloride (Standard); CP-16533-1 hydrochloride (Standard)	Reference Standards Calcium Channel P-glycoprotein Cytochrome P450	Cardiovascular Disease Cancer
Verapamil (hydrochloride) (Standard) is the analytical standard of Verapamil (hydrochloride). This product is intended for research and analytical applications. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

HY-10550R

Tariquidar (Standard) XR9576 (Standard)	Reference Standards P-glycoprotein	Cancer
Tariquidar (Standard) is the analytical standard of Tariquidar. This product is intended for research and analytical applications. Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM) .

HY-14275R

Verapamil (Standard) (±)-Verapamil (Standard); CP-16533-1 (Standard)	Calcium Channel P-glycoprotein Cytochrome P450 Reference Standards	Cardiovascular Disease Metabolic Disease Cancer
Verapamil (Standard) is the analytical standard of Verapamil. This product is intended for research and analytical applications. Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-W035709R

Hydrocinchonine (Standard) Dihydrocinchonine (Standard)	Reference Standards P-glycoprotein Apoptosis	Cancer
Hydrocinchonine (Dihydrocinchonine) (Standard) is the analytical standard of Hydrocinchonine (HY-W035709). This product is used for research and analytical purposes.Hydrocinchonine is a multidrug resistance (MDR)-reversal agent. Hydrocinchonine directly inhibits the function and expression of *P-gp, which is the mechanism by which it reverses MDR. Hydrocinchonine exerts synergistic apoptotic* effect with Paclitaxel (HY-B0015) in MES-SA/DX5 cells. Hydrocinchonine can be used for the study of gynecological malignant tumors (such as uterine sarcoma) with drug resistance caused by excessive expression of P-gp .

HY-N6684R

Deoxynivalenol (Standard) Vomitoxin (Standard)	P-glycoprotein Reference Standards	Metabolic Disease
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-10440R

Vismodegib (Standard) GDC-0449 (Standard)	Reference Standards Hedgehog Autophagy	Cancer
Vismodegib (Standard) is the analytical standard of Vismodegib. This product is intended for research and analytical applications. Vismodegib (GDC-0449) is a BBB-permeable and orally active hedgehog pathway inhibitor with an IC₅₀ of 3 nM. Vismodegib also inhibits *P-gp, ABCG2* with IC₅₀ values of 3.0 μM and 1.4 μM, respectively .

HY-108694R

γ-Tocotrienol (Standard)	Reference Standards Endogenous Metabolite NF-κB	Metabolic Disease Inflammation/Immunology
γ-Tocotrienol (Standard) is the analytical standard of γ-Tocotrienol. This product is intended for research and analytical applications. γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a novel radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment .

HY-N7120R

Penicillin G procaine hydrate (Standard) PGP hydrate (Standard)	Reference Standards Bacterial Antibiotic	Infection
Penicillin G procaine (hydrate) (Standard) is the analytical standard of Penicillin G procaine (hydrate). This product is intended for research and analytical applications. Penicillin G Procaine hydrate (PGP hydrate), a β-lactam antibiotic, is a crystalline complex produced by chemically combining penicillin G with procaine .

HY-B0777R

Moxidectin (Standard) CL301423 (Standard)	Antibiotic BCRP P-glycoprotein Parasite Reference Standards	Infection
Moxidectin (Standard) is the analytical standard of Moxidectin. This product is intended for research and analytical applications. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk .

HY-W001601R

Budipine (Standard)	Reference Standards iGluR	Neurological Disease
Budipine (Standard) is the analytical standard of Budipine. This product is intended for research and analytical applications. Budipine is an anti-parkinson agent. Budipine also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine can be used for the research of CNS disorders include Parkinson disease .

HY-100750R

Norverapamil hydrochloride (Standard) (±)-Norverapamil hydrochloride (Standard); D591 hydrochloride (Standard)	Reference Standards Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil (hydrochloride) (Standard) is the analytical standard of Norverapamil (hydrochloride). This product is intended for research and analytical applications. Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-50671R

Zosuquidar trihydrochloride (Standard) RS 33295-198 trihydrochloride (Standard); LY-335979 trihydrochloride (Standard)	Reference Standards P-glycoprotein	Cancer
Zosuquidar (trihydrochloride) (Standard) is the analytical standard of Zosuquidar (trihydrochloride). This product is intended for research and analytical applications. Zosuquidar (LY335979) trihydrochloride is a P-glycoprotein (P-gp) inhibitor (K_i=59 nM). Zosuquidar trihydrochloride shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research .

HY-N11422R

Mycaminosyltylonolide (Standard)	Reference Standards Antibiotic Bacterial	Infection
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N4108R

Hypophyllanthin (Standard)	Reference Standards P-glycoprotein	Inflammation/Immunology Cancer
Hypophyllanthin (Standard) is the analytical standard of Hypophyllanthin. This product is intended for research and analytical applications. Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .

HY-50880R

Elacridar hydrochloride (Standard) GF120918A (Standard)	P-glycoprotein BCRP Reference Standards	Cancer
Elacridar (hydrochloride) (Standard) is the analytical standard of Elacridar (hydrochloride). This product is intended for research and analytical applications. Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer .

HY-B0501R

Danofloxacin mesylate (Standard) CP 76136-27 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Danofloxacin mesylate (Standard) is the analytical standard of Danofloxacin mesylate. This product is intended for research and analytical applications. Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters (P-gp and MRP2) .

HY-W009141R

1-Monopalmitin (Standard) Glyceryl palmitate (Standard)	Reference Standards Apoptosis P-glycoprotein PI3K IAP Caspase Akt	Cancer
1-Monopalmitin (Glyceryl palmitate) (Standard) is the analytical standard of 1-Monopalmitin (HY-W009141). This product is intended for research and analytical applications. 1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells .

HY-17367AR

Atazanavir sulfate (Standard) BMS-232632 sulfate (Standard)	Reference Standards HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite	Infection Cancer
Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-N2453R

Convallatoxin (Standard)	Reference Standards PPAR NF-κB P-glycoprotein	Inflammation/Immunology Cancer
Convallatoxin (Standard) is the analytical standard of Convallatoxin. This product is intended for research and analytical applications. Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-17367R

Atazanavir (Standard) BMS-232632 (Standard)	Reference Standards HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite	Infection Cancer
Atazanavir (Standard) is the analytical standard of Atazanavir. This product is intended for research and analytical applications. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death .

HY-N6015R

Bacopasaponin C (Standard)	Reference Standards Parasite P-glycoprotein	Infection Cancer
Bacopasaponin C (Standard) is the analytical standard of Bacopasaponin C (HY-N6015). This product is intended for research and analytical applications. Bacopasaponin C is an orally active natural glycoside. Bacopasaponin C can be isolated from Bacopa monniera. Bacopasaponin C inhibits Verapamil (HY-14275)-stimulated *P-gp* ATPase activity with an IC₅₀ of 57.83 μg/mL. Bacopasaponin C has antitumor activity against sarcomas. Bacopasaponin C has antiparasitic activity against Leishmania donovani .

HY-101791R

P-gp inhibitor 1 (Standard)	Reference Standards P-glycoprotein	Cancer
P-gp inhibitor 1 (Standard) is the analytical standard of P-gp inhibitor 1 (HY-101791). This product is intended for research and analytical applications. P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance.

HY-N3584R

Paris saponin VII (Standard) Chonglou Saponin VII (Standard)	Reference Standards Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-16958R

PD 404182 (Standard)	Antibiotic Dimethylargininase (DDAH) Reference Standards	Inflammation/Immunology
Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N0566R

23-Hydroxybetulinic acid (Standard) Anemosapogenin (Standard)	Reference Standards Apoptosis Autophagy Bcl-2 Family Caspase Survivin p38 MAPK MMP	Cancer
23-Hydroxybetulinic acid (Standard) is the analytical standard of 23-Hydroxybetulinic acid (HY-N0566). This product is intended for research and analytical applications. 23-Hydroxybetulinic acid (Anemosapogenin) is an orally active triterpenoid with broad-spectrum anticancer activity. 23-Hydroxybetulinic acid reduces the levels of Bcl-2 and survivin, elevates the level of Bax, promotes the cleavage/activation of caspase-3 and caspase-9, and induces apoptosis via the endogenous mitochondrial pathway involving cytochrome C release and mitochondrial membrane potential disruption. 23-Hydroxybetulinic acid arrests the cell cycle at S and G1 phases, inhibits cancer cell proliferation, blocks the MAPK signaling pathway, regulates MMP2, and induces autophagic apoptosis by upregulating beclin-1. 23-Hydroxybetulinic acid inhibits the activity and efflux function of P-gp, increases the intracellular accumulation of chemotherapeutic drugs, and synergistically enhances cytotoxicity with Doxorubicin (HY-15142). 23-Hydroxybetulinic acid inhibits the phosphorylation and nuclear translocation of STAT6, blocks M2 macrophage polarization, and reduces M2 macrophage-mediated apoptosis resistance of colon cancer cells. 23-Hydroxybetulinic acid can be used in related studies on chronic myeloid leukemia, hepatocellular carcinoma, sarcoma 180, multidrug-resistant breast cancer, leukemia, Doxorubicin-induced cardiotoxicity, and colorectal cancer.

HY-10550AR

Tariquidar methanesulfonate, hydrate (Standard) XR9576 methanesulfonate, hydrate (Standard)	Reference Standards P-glycoprotein	Cancer
Tariquidar (methanesulfonate, hydrate) (Standard) is the analytical standard of Tariquidar (methanesulfonate, hydrate). This product is intended for research and analytical applications. Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM.

HY-17013AR

Dofequidar fumarate (Standard) MS-209 (Standard)	P-glycoprotein Reference Standards	Cancer
Dofequidar (fumarate) (Standard) is the analytical standard of Dofequidar (fumarate). This product is intended for research and analytical applications. Dofequidar fumarate (MS-209) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar fumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect .

HY-107643R

Reversan (Standard) CBLC4H10 (Standard)	Reference Standards P-glycoprotein	Cancer
Reversan (Standard) is the analytical standard of Reversan (HY-107643). This product is intended for research and analytical applications. Reversan (CBLC4H10) inhibits drug efflux mediated by P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP1), and exhibits oral activity. Reversan shows activity against glioblastoma multiforme and neuroblastoma models .

HY-108286R

Talinolol (Standard) Cordanum (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Talinolol (Standard) is the analytical standard of Talinolol (HY-108286). This product is intended for research and analytical applications. Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .

HY-10010R

Ko 143 (Standard)	BCRP Reference Standards	Cancer
Ko 143 (Standard) is the analytical standard of Ko 143 (HY-10010). This product is intended for research and analytical applications. Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters .

HY-106004R

Zamicastat (Standard) BIA 5-1058 (Standard)	Reference Standards Dopamine β-hydroxylase P-glycoprotein BCRP	Cardiovascular Disease Cancer
Zamicastat (Standard) is the analytical standard of Zamicastat (HY-106004). This product is intended for research and analytical applications. Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC₅₀ values of 73.8 μM and 17.0 μM, respectively . Zamicastat reduces high blood pressure .

Cat. No.	상품명	Category	Target	Chemical Structure