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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
PLN
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "PLN" in MCE Product Catalog:
3
Target:
Research Areas:
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung .
1
Cat. No.: HY-47888
CAS No.: 2408065-32-5
Target:
Research Areas:
PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder.
Cat. No.: HY-148776
Cat. No.: HY-137561A
CAS No.: 2775365-40-5
Synonyms: PLN-74809 hydrochloride
Target:
Research Areas:
Bexotegrast hydrochloride (PLN-74809 hydrochloride) is a small molecule dual selective inhibitor with activity targeting αVβ1 and αVβ6. Bexotegrast hydrochloride is used for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). Bexotegrast hydrochloride inhibits the activation of TGF-β1 by blocking the function of these integrins, thereby preventing the growth of fibrous tissue in the lungs and bile ducts .
Cat. No.: HY-RS10727
Target:
Research Areas:
PLN Human Pre-designed siRNA Set A contains three designed siRNAs for PLN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17361
Target:
Research Areas:
Pln Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pln gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23815
Target:
Research Areas:
Pln Rat Pre-designed siRNA Set A contains three designed siRNAs for Pln gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P81873A
Synonyms: PLN; PLB; Cardiac phospholamban; PLB
Cat. No.: HY-P74766
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELL; Lymphocyte Adhesion Molecule 1; Prev. LYAM1; Gp90-MEL; Prev. LNHR; Lyam-1; L-Selectin; LECAM1; LAM-1; HLHRc; PLNHR; Leu-8; CD62L; TQ1; LSEL; Leukocyte Adhesion Molecule 1; LAM1; PLN Homing Receptor; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74767
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELL; Lymphocyte Adhesion Molecule 1; Prev. LYAM1; Gp90-MEL; Prev. LNHR; Lyam-1; L-Selectin; LECAM1; LAM-1; HLHRc; PLNHR; Leu-8; CD62L; TQ1; LSEL; Leukocyte Adhesion Molecule 1; LAM1; PLN Homing Receptor; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD
Species:
Human
Source:
CHO
Cat. No.: HY-P74768
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELL; Lymphocyte Adhesion Molecule 1; Prev. LYAM1; Gp90-MEL; Prev. LNHR; Lyam-1; L-Selectin; LECAM1; LAM-1; HLHRc; PLNHR; Leu-8; CD62L; TQ1; LSEL; Leukocyte Adhesion Molecule 1; LAM1; PLN Homing Receptor; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD
Species:
Human
Source:
HEK293
Cat. No.: HY-P76638
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELL; Lymphocyte Adhesion Molecule 1; Prev. LYAM1; Gp90-MEL; Prev. LNHR; Lyam-1; L-Selectin; LECAM1; LAM-1; HLHRc; PLNHR; Leu-8; CD62L; TQ1; LSEL; Leukocyte Adhesion Molecule 1; LAM1; PLN Homing Receptor; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD
Species:
Rat
Source:
HEK293
Cat. No.: HY-P77483
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELL; Lymphocyte Adhesion Molecule 1; Prev. LYAM1; Gp90-MEL; Prev. LNHR; Lyam-1; L-Selectin; LECAM1; LAM-1; HLHRc; PLNHR; Leu-8; CD62L; TQ1; LSEL; Leukocyte Adhesion Molecule 1; LAM1; PLN Homing Receptor; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P70312
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELL; Lymphocyte Adhesion Molecule 1; Prev. LYAM1; Gp90-MEL; Prev. LNHR; Lyam-1; L-Selectin; LECAM1; LAM-1; HLHRc; PLNHR; Leu-8; CD62L; TQ1; LSEL; Leukocyte Adhesion Molecule 1; LAM1; PLN Homing Receptor; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
