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Poria cocos

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By Targets:	Akt (2) AMPK (1) Apoptosis (4) Autophagy (2) Caspase (3) Drug Derivative (1) Endogenous Metabolite (2) Interleukin Related (1) JNK (2) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) MDM-2/p53 (2) NF-κB (1) NO Synthase (1) PARP (2) PTEN (2) Reactive Oxygen Species (ROS) (1) Reference Standards (4) TGF-beta/Smad (1) TNF Receptor (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (2)
Oligonucleotides:	Nucleoside Analogs (1) Uridine (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2995

Poricoic acid A 1 Publications Verification Poricoic acid A(F)	NF-κB Keap1-Nrf2 AMPK TGF-beta/Smad Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin .

HY-W006429

L-Uridine	Endogenous Metabolite	Others
L-Uridine is an enantiomer of the normal RNA constituent D-uridine. L-Uridine can be isolated from the Polyporaceae fungus Poria cocos (Schw.). L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases .

HY-N2993

Polyporenic acid C	Apoptosis Caspase PARP Akt PTEN MDM-2/p53 JNK	Cancer
Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer .

HY-N2499

Dehydrotumulosic acid	Others	Metabolic Disease
Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

HY-N4124

Poricoic acid B	NO Synthase TNF Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology
Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases ^[3].

HY-N2990

16α-Hydroxydehydrotrametenolic acid 3β,16α-Dihydroxylanosta-7,9(11),24-trien-21-oic acid	Others	Inflammation/Immunology
16α-Hydroxydehydrotrametenolic acid is a triterpene Acid in fermented mycelia of edible fungus Poria cocos .

HY-N2991

Dehydropachymic acid	Autophagy	Neurological Disease
Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid is more effective in autophagy-lysosome pathway (ALP) impaired cells rather than normal cells .

HY-N2177

3-Dehydrotrametenolic acid	Lactate Dehydrogenase Apoptosis	Cancer
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity .

HY-N2994

3-O-Acetyl-16α-hydroxytrametenolic acid	Others	Cancer
3-O-Acetyl-16α-hydroxytrametenolic acid (Compound 3) is a triterpene found in Poria cocos, with anti-oxidant and anti-cancer activity .

HY-N2490

Dehydrotrametenolic acid	Caspase Apoptosis	Inflammation/Immunology Cancer
Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects .

HY-N2142

3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B	Others	Cancer
3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B is a chemical constituent of the plant Poria cocos .

HY-N18767

Poria cocos extract	Others	Others
Poria Cocos Extract is obtained from the dried sclerotia of the fungus Poria cocos. It has a variety of skin care effects and is widely used in functional cosmetics.

HY-N2499R

Dehydrotumulosic acid (Standard)	Reference Standards Others	Metabolic Disease
Dehydrotumulosic acid (Standard) is the analytical standard of Dehydrotumulosic acid. This product is intended for research and analytical applications. Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

HY-N10071

Poricoic acid G	Others	Cancer
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-N13070

3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid	Others	Metabolic Disease
3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid (compound 89) can be isolated from the secretions of the fungus Poria cocos (Schw.) .

HY-N2991R

Dehydropachymic acid (Standard)	Reference Standards Autophagy	Neurological Disease
Dehydropachymic acid (Standard) is the analytical standard of Dehydropachymic acid. This product is intended for research and analytical applications. Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid is more effective in autophagy-lysosome pathway (ALP) impaired cells rather than normal cells .

HY-N2993R

Polyporenic acid C (Standard)	Reference Standards Apoptosis Caspase PARP Akt PTEN MDM-2/p53 JNK	Cancer
Polyporenic acid C (Standard) is an analytical standard of Polyporenic acid C (HY-N2993). This product is intended for research and analytical applications. Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer .

HY-N8978

Poricoic acid AE	Drug Derivative	Others
Poricoic acid AE is a natural triterpene.

HY-W006429R

L-Uridine (Standard)	Endogenous Metabolite Reference Standards	Others
L-Uridine (Standard) is the analytical standard of L-Uridine (HY-W006429). This product is intended for research and analytical applications. L-Uridine is an enantiomer of the normal RNA constituent D-uridine. L-Uridine can be isolated from the Polyporaceae fungus Poria cocos (Schw.). L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases .

Poricoic acid A 1 Publications Verification Poricoic acid A(F)	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Source Classification Cancer	NF-κB Keap1-Nrf2 AMPK TGF-beta/Smad Reactive Oxygen Species (ROS)
Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin .

L-Uridine	Natural Products Classification of Application Fields Polyporaceae Metabolic Disease Poria cocos Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
L-Uridine is an enantiomer of the normal RNA constituent D-uridine. L-Uridine can be isolated from the Polyporaceae fungus Poria cocos (Schw.). L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases .

Polyporenic acid C	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Source Classification Cancer	Apoptosis Caspase PARP Akt PTEN MDM-2/p53 JNK
Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer .

Dehydrotumulosic acid	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Metabolic Disease Poria cocos Plants Disease Research Fields Source Classification	Others
Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

Poricoic acid B	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Source Classification Cancer	NO Synthase TNF Receptor Interleukin Related
Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases ^[3].

16α-Hydroxydehydrotrametenolic acid 3β,16α-Dihydroxylanosta-7,9(11),24-trien-21-oic acid	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Inflammation/Immunology Source Classification	Others
16α-Hydroxydehydrotrametenolic acid is a triterpene Acid in fermented mycelia of edible fungus Poria cocos .

Dehydropachymic acid	Triterpenes Terpenoids Polyporaceae Poria cocos Plants Source Classification	Autophagy
Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid is more effective in autophagy-lysosome pathway (ALP) impaired cells rather than normal cells .

3-Dehydrotrametenolic acid	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Source Classification Cancer	Lactate Dehydrogenase Apoptosis
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity .

3-O-Acetyl-16α-hydroxytrametenolic acid	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Cancer Source Classification	Others
3-O-Acetyl-16α-hydroxytrametenolic acid (Compound 3) is a triterpene found in Poria cocos, with anti-oxidant and anti-cancer activity .

Dehydrotrametenolic acid	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Inflammation/Immunology Disease Research Fields Source Classification	Caspase Apoptosis
Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects .

3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B	Classification of Application Fields Polyporaceae Poria cocos Plants Disease Research Fields Steroids Source Classification Cancer	Others
3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B is a chemical constituent of the plant Poria cocos .

Poria cocos extract	Structural Classification Extract	Others
Poria Cocos Extract is obtained from the dried sclerotia of the fungus Poria cocos. It has a variety of skin care effects and is widely used in functional cosmetics.

Dehydrotumulosic acid (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Poria cocos Plants Source Classification	Reference Standards Others
Dehydrotumulosic acid (Standard) is the analytical standard of Dehydrotumulosic acid. This product is intended for research and analytical applications. Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

Poricoic acid G	Microorganisms Ketones, Aldehydes, Acids Source Classification	Others
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid	Triterpenes Structural Classification Microorganisms Terpenoids Source Classification	Others
3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid (compound 89) can be isolated from the secretions of the fungus Poria cocos (Schw.) .

Dehydropachymic acid (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Poria cocos Plants Source Classification	Reference Standards Autophagy
Dehydropachymic acid (Standard) is the analytical standard of Dehydropachymic acid. This product is intended for research and analytical applications. Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid is more effective in autophagy-lysosome pathway (ALP) impaired cells rather than normal cells .

Polyporenic acid C (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Poria cocos Plants Source Classification	Reference Standards Apoptosis Caspase PARP Akt PTEN MDM-2/p53 JNK
Polyporenic acid C (Standard) is an analytical standard of Polyporenic acid C (HY-N2993). This product is intended for research and analytical applications. Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer .

Poricoic acid AE	Triterpenes Structural Classification Microorganisms Terpenoids Source Classification	Drug Derivative
Poricoic acid AE is a natural triterpene.

L-Uridine (Standard)	Structural Classification Natural Products Polyporaceae Poria cocos Plants Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
L-Uridine (Standard) is the analytical standard of L-Uridine (HY-W006429). This product is intended for research and analytical applications. L-Uridine is an enantiomer of the normal RNA constituent D-uridine. L-Uridine can be isolated from the Polyporaceae fungus Poria cocos (Schw.). L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases .

Cat. No.	Product Name		Classification

HY-W006429

L-Uridine		Nucleoside Analogs Uridine
L-Uridine is an enantiomer of the normal RNA constituent D-uridine. L-Uridine can be isolated from the Polyporaceae fungus Poria cocos (Schw.). L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases .

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Poria cocos

Inhibitors & Agonists

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Oligonucleotides

Natural
Products