465-18-9
465-18-9
Chemical Structure
Polyporenic acid C
- CAS No.: 465-18-9
- Formula:C31H46O4
- Molecular Weight:482.69
IUPAC Name: (R)-2-((5R,10S,13R,14R,16R,17R)-16-hydroxy-4,4,10,13,14-pentamethyl-3-oxo-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methyl-5-methyleneheptanoic acid
InChIKey: KPKYWYZPIVAHKU-WMNQUVFJSA-N
SMILES: C[C@]12[C@@]([C@]([C@H](C(O)=O)CCC(C(C)C)=C)([H])[C@H](O)C1)(CC=C3C2=CC[C@](C4(C)C)([H])[C@@]3(CCC4=O)C)C
Biological Activity: Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer[1].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Polyporenic acid C | 98.81% | Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer. | ||||||||||||||||||||
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Polyporenic acid C (Standard) | ≥98% | Polyporenic acid C (Standard) is an analytical standard of Polyporenic acid C (HY-N2993). This product is intended for research and analytical applications. Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer. | ||||||||||||||||||||
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3-Epidehydrotumulosic acid | 99.49% | 3-Epidehydrotumulosic acid has inhibitory activity against AAPH-induced lysis of red blood cells. | ||||||||||||||||||||
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16-O-Acetylpolyporenic acid C | 16-O-Acetylpolyporenic acid C is a natural triterpene. | |||||||||||||||||||||
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Dehydrotrametenolic acid | 99.95% | Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects. | ||||||||||||||||||||
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Dehydrotumulosic acid | 99.06% | Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body. | ||||||||||||||||||||
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16α-Hydroxydehydrotrametenolic acid | 99.46% | 16α-Hydroxydehydrotrametenolic acid is a triterpene Acid in fermented mycelia of edible fungus Poria cocos. | ||||||||||||||||||||
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Dehydropachymic acid (Standard) | ≥98% | Dehydropachymic acid (Standard) is the analytical standard of Dehydropachymic acid. This product is intended for research and analytical applications. Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid is more effective in autophagy-lysosome pathway (ALP) impaired cells rather than normal cells. | ||||||||||||||||||||
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Poricoic acid A | 99.32% | Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin. | ||||||||||||||||||||
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3-Epidehydropachymic acid | 3-Epidehydropachymic acid, a lanostane triterpenoid, shows totoxicity effect against human acute monocytic leukemia cell line THP-1 (IC50=52.51 μM). | |||||||||||||||||||||
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Poricoic acid AM | 99.25% | Poricoic acid AM is a triterpenoid with ant-tumor activities. | ||||||||||||||||||||
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16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid | 16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid is a lanostanoid that can be found in the Sri Lankan basidiomycete Ganoderma applanatum. | |||||||||||||||||||||
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