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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1268 Results for "
Purines
" in MedChemExpress (MCE) Product Catalog:
Products (1268)
1268 Results for "Purines" in MCE Product Catalog:
111
Research Areas:
Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .
80
80 Cited Publications
Synonyms: Amethopterin; CL14377; WR19039
Research Areas:
Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
80
80 Cited Publications
Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate
80
80 Cited Publications
Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium
Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
24
24
24 Cited Publications
Synonyms: 6-Aminopurine hemisulfate; Vitamin B4 hemisulfate
24
24 Cited Publications
Synonyms: 6-Aminopurine hydrochloride; Vitamin B4 hydrochloride
24
24 Cited Publications
Cat. No.: HY-W015213
CAS No.: 6055-72-7
22
22 Cited Publications
Cat. No.: HY-W011012
CAS No.: 4578-31-8
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20 Cited Publications
Cat. No.: HY-16209
CAS No.: 284490-13-7
Synonyms: BCX-1777 hydrochloride; Immucillin-H hydrochloride
Research Areas:
Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels .
20
Research Areas:
Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels .
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18 Cited Publications
Synonyms: Mercaptopurine; 6-MP
18
18 Cited Publications
Synonyms: Mercaptopurine hydrate; 6-MP hydrate
Target:
Research Areas:
6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
16
Category:
Natural Products Microorganisms Other Diseases Disease markers Endogenous metabolite Disease Research Fields Cancer
Target:
16
13
13
13 Cited Publications
Cat. No.: HY-B0199A
CAS No.: 116680-01-4
Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride
Target:
12
12 Cited Publications
Synonyms: TEI 6720; TMX 67
Target:
Research Areas:
Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout .
11
Category:
Natural Products Anti-aging Endocrine diseases Endogenous metabolite Infection Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Disease Research Fields
Target:
10
10 Cited Publications
Synonyms: 2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA
Target:
Research Areas:
Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
