128794-94-5
Chemical Structure
Mycophenolate Mofetil
Synonym(s): RS 61443; TM-MMF
- CAS No.: 128794-94-5
- Formula:C23H31NO7
- Molecular Weight:433.49
IUPAC Name: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate
InChIKey: RTGDFNSFWBGLEC-SYZQJQIISA-N
SMILES: O=C(OCCN1CCOCC1)CC/C(C)=C/CC2=C(O)C3=C(COC3=O)C(C)=C2OC
Biological Activity: Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mycophenolate Mofetil | 99.83% | Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation. | ||||||||||||||||||||
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Mycophenolate Mofetil (Standard) | 99.86% | Mycophenolate Mofetil (Standard) is the analytical standard of Mycophenolate Mofetil. This product is intended for research and analytical applications. Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection). | ||||||||||||||||||||
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Mycophenolate Mofetil-d4 | 99.80% | Mycophenolate Mofetil-d4 is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection). | ||||||||||||||||||||
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Similarity Score 0.99
HY-B0199AMycophenolate mofetil hydrochloride -
Similarity Score 0.89
HY-Z19687Mycophenolate impurity 3 -
Similarity Score 0.87
HY-Z8510Mycophenolate impurity 1 -
Similarity Score 0.84
HY-Z8512Mycophenolate impurity 4 -
Similarity Score 0.78
HY-137238Ethyl mycophenolate -
Similarity Score 0.76
HY-113972A(E/Z)-Methyl mycophenolate -
Similarity Score 0.76
HY-113972RMethyl mycophenolate (Standard) -
Similarity Score 0.75
HY-B0421AMycophenolic acid sodium -
Similarity Score 0.73
HY-B0421S2Mycophenolic acid-13C17 -
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