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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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RBL-2H3 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (3) Biochemical Assay Reagents (1) Calcium Channel (2) Cannabinoid Receptor (1) Cholinesterase (ChE) (1) Complement System (1) COX (3) Drug Derivative (2) Endogenous Metabolite (7) Environmental Pollutants (1) ERK (1) Fc Receptor (FcR) (1) Formyl Peptide Receptor (FPR) (1) Fungal (1) Glycosidase (4) Histamine Receptor (1) Interleukin Related (4) JNK (1) Keap1-Nrf2 (1) Leukotriene Receptor (2) LPL Receptor (2) MMP (1) NF-κB (1) NO Synthase (2) P-glycoprotein (2) P2Y Receptor (2) p38 MAPK (3) PGE synthase (1) PKC (1) Prostaglandin Receptor (2) Reactive Oxygen Species (ROS) (1) Reference Standards (1) STAT (1) Syk (2) TNF Receptor (4) TRP Channel (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (4) Infection (4) Inflammation/Immunology (20) Metabolic Disease (4) Neurological Disease (7)

By Targets:

Bacterial (3)

Biochemical Assay Reagents (1)

Calcium Channel (2)

Cannabinoid Receptor (1)

Cholinesterase (ChE) (1)

Complement System (1)

COX (3)

Drug Derivative (2)

Endogenous Metabolite (7)

Environmental Pollutants (1)

ERK (1)

Fc Receptor (FcR) (1)

Formyl Peptide Receptor (FPR) (1)

Fungal (1)

Glycosidase (4)

Histamine Receptor (1)

Interleukin Related (4)

JNK (1)

Keap1-Nrf2 (1)

Leukotriene Receptor (2)

LPL Receptor (2)

MMP (1)

NF-κB (1)

NO Synthase (2)

P-glycoprotein (2)

P2Y Receptor (2)

p38 MAPK (3)

PGE synthase (1)

PKC (1)

Prostaglandin Receptor (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

STAT (1)

Syk (2)

TNF Receptor (4)

TRP Channel (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (3)

Cardiovascular Disease (4)

Infection (4)

Inflammation/Immunology (20)

Metabolic Disease (4)

Neurological Disease (7)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19989

MK-571 Maximum Cited Publications 33 Publications Verification L-660711	P-glycoprotein LPL Receptor Leukotriene Receptor	Inflammation/Immunology
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .

HY-19989A

MK-571 sodium Maximum Cited Publications 33 Publications Verification L-660711 sodium	P-glycoprotein LPL Receptor Leukotriene Receptor	Inflammation/Immunology
MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .

HY-N6070A

Ricinoleic acid (purity≥99%)	Environmental Pollutants Prostaglandin Receptor	Inflammation/Immunology
Ricinoleic acid (purity≥99%), a hydroxy fatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC₅₀ in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .

HY-N2252

Licarin A (+)-Licarin A	TNF Receptor Prostaglandin Receptor COX	Neurological Disease Metabolic Disease Inflammation/Immunology
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression .

HY-N2426

Clerodendrin	Interleukin Related	Inflammation/Immunology
Clerodendrin is a nature product could be isolated from Lobelia chinensis. Clerodendrin is a potent dual Interleukin-4 (IL-4) inhibitor and β-hexosaminidase (Hex) inhibitor .

HY-P10724

fMIFL	Formyl Peptide Receptor (FPR) Bacterial	Infection
fMIFL is a formyl tetrapeptide derived from Staphylococcus aureus, and also an agonist of mouse formyl peptide receptor 1 (mFPR1). It exhibits nanomolar activity against mFPR1 and micromolar activity against mFPR2. fMIFL is applicable to studies related to bacterial infections .

HY-W159754

Chavicol p-Hydroxyallylbenzene	Cholinesterase (ChE)	Inflammation/Immunology
Chavicol (p-Hydroxyallylbenzene) is a phenylpropane compound. Chavicol can be isolated from the bark of Sassafras tzumu. Chavicol exhibits Acetylcholinesterase inhibitory activity (IC₅₀ = 7.42 μM). Chavicol produces a 3% inhibitory effect on antigen-IgE-mediated degranulation in mast cells .

HY-116474

Viridicatol	ERK JNK MMP p38 MAPK STAT Fungal Bacterial NO Synthase PGE synthase NF-κB Wnt β-catenin	Infection Metabolic Disease Inflammation/Immunology
Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis .

HY-N2173

Forsythoside E 1 Publications Verification	Others	Cardiovascular Disease Inflammation/Immunology
Forsythoside E is a phenylethanoid glycoside compound. Forsythoside E can be isolated from Shuanghuanglian. Forsythoside E does not induce vascular leakage or promote histamine release in mice. Forsythoside E does not cause pseudo-allergic reactions .

HY-P1640

(Trp63,Trp64)-C3a(63-77)	Complement System	Inflammation/Immunology
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca ²⁺ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC₅₀ of 9.5, 2.0 and 0.8 nM, respectively .

HY-N7292

Bakkenolide B	NO Synthase Keap1-Nrf2	Inflammation/Immunology
Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma .

HY-N15708

Dichotomine C (R)-(-)-Dichotomine C	Glycosidase TNF Receptor Interleukin Related	Inflammation/Immunology
Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC₅₀ of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC₅₀s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions .

HY-N12116

Maceneolignan A	TNF Receptor	Cancer
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae). Maceneolignan A inhibits the release of β-hexosaminidase in RBL-2H3 cells, with an IC₅₀ of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC₅₀ of 63.7 μM .

HY-139247

pNPS-DHA	Drug Derivative	Inflammation/Immunology
pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC₅₀ of 15 μM .

HY-P11163

Eumenitin	Bacterial Glycosidase	Infection
Eumenitin is an antibacterial peptide with strong membrane activity, broad-spectrum antibacterial activity, and almost no hemolytic toxicity. Eumenitin has inhibitory effects on various Gram positive and Gram negative bacteria. Eumenitin can induce the release of β-hexosaminidase from rat peritoneal mast cells and RBL-2H3 cells. Eumenitin can be used in the research of infectious conditions .

HY-138961

ER-27319 1 Publications Verification	Syk	Inflammation/Immunology
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases .

HY-116295

MRS2690	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 is a selective P2Y14 receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease .

HY-116295A

MRS2690 disodium	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease .

HY-N2426R

Clerodendrin (Standard)	Reference Standards Interleukin Related	Inflammation/Immunology
Desvenlafaxine (Standard) is the analytical standard of Desvenlafaxine. This product is intended for research and analytical applications. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-N8426

4'-O-Methylnyasol Ellisinin A	Histamine Receptor	Cancer
4'-O-Methylnyasol is an inhibitor of β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

HY-108489

ER-27319 maleate 1 Publications Verification	Syk	Inflammation/Immunology
ER-27319 (maleate), an acridone derivative, is a potent and selective SKY inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 (maleate) inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases ^[1] ^[2].

HY-121557

OMDM-1	Endogenous Metabolite	Neurological Disease
OMDM-1 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 2.4 μM .

HY-135880A

OMDM-4	Endogenous Metabolite	Neurological Disease
OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i 17.7 μM .

HY-135882

OMDM-6	TRP Channel Cannabinoid Receptor Endogenous Metabolite	Neurological Disease
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM .

HY-135881

OMDM-5	TRP Channel Endogenous Metabolite	Neurological Disease
OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a K_i of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC₅₀ of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (K_i=4.9 μM) .

HY-135880

OMDM-3	Endogenous Metabolite	Neurological Disease
OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 16.6 μM .

HY-103342

OMDM-2	Endogenous Metabolite	Neurological Disease
OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 3.0 μM .

HY-N19797

Dichotomoside A	Drug Derivative	Others
Dichotomoside A is a neolignan glycoside. Dichotomoside A can be isolated from the roots of Stellaria dichotoma L. var. lanceolata .

HY-149151

Variegatic acid	Endogenous Metabolite PKC Glycosidase TNF Receptor Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced β-hexosaminidase release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

HY-N11725

Phlorofucofuroeckol A	Fc Receptor (FcR)	Inflammation/Immunology
Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits β-hexosaminidase release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease .

HY-P11646

Brazzein	COX	Metabolic Disease Inflammation/Immunology
Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities. Brazzein inhibits COX-2 with an IC₅₀ of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC₅₀ = 12.55 μM) . Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation .

HY-N19858

Millettiasaponin B	Others	Cancer
Millettiasaponin B is an oleanane-type triterpene saponin found in the roots of Millettia speciosa. Millettiasaponin B can be used in leukemia research .

HY-N18182

Mudanpioside E	Glycosidase	Inflammation/Immunology
Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC₅₀ of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases .

HY-N19857

Millettiasaponin A	Biochemical Assay Reagents	Cardiovascular Disease Metabolic Disease
Millettiasaponin A is an oleanane-type triterpenoid saponin found in the stems of Derris eriocarpa and roots of Millettia speciosa. Millettiasaponin A is 150 times sweeter than Sucrose (HY-B1779) at 1% concentration. Millettiasaponin A can be used in research on hypertension and obesity. .

HY-182610

ISP-VT Isopropyl vanillate	COX Interleukin Related	Inflammation/Immunology
ISP-VT (Isopropyl vanillate) is a COX-2 inhibitor. ISP-VT exhibits anti-inflammatory, antipyretic and immunomodulatory activities. ISP-VT reduces neutrophil migration and the release of inflammatory factors . ISP-VT can be used for the research of inflammatory and immune diseases and other conditions .

Cat. No.	Product Name	Target	Research Area

HY-P10724

fMIFL	Formyl Peptide Receptor (FPR) Bacterial	Infection
fMIFL is a formyl tetrapeptide derived from Staphylococcus aureus, and also an agonist of mouse formyl peptide receptor 1 (mFPR1). It exhibits nanomolar activity against mFPR1 and micromolar activity against mFPR2. fMIFL is applicable to studies related to bacterial infections .

HY-P1640

(Trp63,Trp64)-C3a(63-77)	Complement System	Inflammation/Immunology
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca ²⁺ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC₅₀ of 9.5, 2.0 and 0.8 nM, respectively .

HY-P11128

Mastoparan-V1	Peptides	Others
Mastoparan-V1 is a peptide belonging to the Mastoparan family. Mastoparan-V1 exhibits modest mast cell degranulation activity, with EC₅₀ of 130.24 μM in RBL-2H3 cells. Mastoparan-V1 can be used for the study of allergic reactions induced by wasp stings .

HY-P11163

Eumenitin	Bacterial Glycosidase	Infection
Eumenitin is an antibacterial peptide with strong membrane activity, broad-spectrum antibacterial activity, and almost no hemolytic toxicity. Eumenitin has inhibitory effects on various Gram positive and Gram negative bacteria. Eumenitin can induce the release of β-hexosaminidase from rat peritoneal mast cells and RBL-2H3 cells. Eumenitin can be used in the research of infectious conditions .

HY-P11646

Brazzein	COX	Metabolic Disease Inflammation/Immunology
Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities. Brazzein inhibits COX-2 with an IC₅₀ of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC₅₀ = 12.55 μM) . Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation .

Licarin A (+)-Licarin A	Monophenols Saururaceae Neurological Disease Classification of Application Fields Simple Phenylpropanols Saururus chinensis (Lour.) Baill. Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	TNF Receptor Prostaglandin Receptor COX
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression .

Clerodendrin	Clerodendrum trichotomum Thunb. Flavonoids Verbenaceae Plants Isoflavones	Interleukin Related
Clerodendrin is a nature product could be isolated from Lobelia chinensis. Clerodendrin is a potent dual Interleukin-4 (IL-4) inhibitor and β-hexosaminidase (Hex) inhibitor .

Viridicatol	Infection Alkaloids Structural Classification Monophenols Microorganisms Classification of Application Fields Phenols Quinoline Alkaloids Disease Research Fields Source Classification	ERK JNK MMP p38 MAPK STAT Fungal Bacterial NO Synthase PGE synthase NF-κB Wnt β-catenin
Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis .

Forsythoside E 1 Publications Verification	Structural Classification Oleaceae Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
Forsythoside E is a phenylethanoid glycoside compound. Forsythoside E can be isolated from Shuanghuanglian. Forsythoside E does not induce vascular leakage or promote histamine release in mice. Forsythoside E does not cause pseudo-allergic reactions .

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