201010-95-9
201010-95-9
Chemical Structure
ER-27319
- CAS No.: 201010-95-9
- Formula:C20H22N2O5
- Molecular Weight:370.40
IUPAC Name: 10-(3-aminopropyl)-3,4-dimethylacridin-9(10H)-one oxalate
InChIKey: IIELZHYJYZBSGG-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC=C2)N(CCCN)C3=C(C)C(C)=CC=C13.O=C(O)C(O)=O
Biological Activity: ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases[1][2].
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ER-27319 | 98.66% | ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases. | ||||||||||||||||||||
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References
- [1]. Katsuhiro Moriya, et al. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcɛ receptor I-mediated activation of Syk. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23): 12539–12544.
- [2]. Yoshitaka Sato, et al. IgG-mediated signal transduction in canine mastocytoma-derived cells. Int Arch Allergy Immunol. 2002 Dec;129(4):305-13. [Content Brief]
Keywords
