199875-69-9
Chemical Structure
N-Arachidonyldopamine
- CAS No.: 199875-69-9
- Formula:C28H41NO3
- Molecular Weight:439.63
IUPAC Name: (5Z,8Z,11Z,14Z)-N-(3,4-dihydroxyphenethyl)icosa-5,8,11,14-tetraenamide
InChIKey: MVVPIAAVGAWJNQ-DOFZRALJSA-N
SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCC1=CC(O)=C(O)C=C1)=O
Biological Activity: N-Arachidonyldopamine acts as an Anandamide (HY-10863) membrane transport inhibitor, a selective CB1 cannabinoid receptor agonist, and a VR1 receptor activator. It exhibits an EC50 value of 48 nM for rat VR1 and a Ki value of 0.25 μM for CB1. N-Arachidonyldopamine exists in mammalian neural tissues. It stimulates intracellular Ca2+ mobilization, mediates cannabinoid-like effects, and induces hypothermia, hypomotility, catalepsy, analgesia, and hyperalgesia to heat. N-Arachidonyldopamine possesses anticancer activity against breast cancer. It can be used in research related to breast cancer and heat hyperalgesia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Arachidonyldopamine | 98.36% | N-Arachidonyldopamine acts as an Anandamide (HY-10863) membrane transport inhibitor, a selective CB1 cannabinoid receptor agonist, and a VR1 receptor activator. It exhibits an EC50 value of 48 nM for rat VR1 and a Ki value of 0.25 μM for CB1. N-Arachidonyldopamine exists in mammalian neural tissues. It stimulates intracellular Ca2+ mobilization, mediates cannabinoid-like effects, and induces hypothermia, hypomotility, catalepsy, analgesia, and hyperalgesia to heat. N-Arachidonyldopamine possesses anticancer activity against breast cancer. It can be used in research related to breast cancer and heat hyperalgesia. | ||||||||||||||||||||
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N-Arachidonyldopamine-d8 | N-Arachidonyldopamine-d8 is the deuterium labeled N-Arachidonyldopamine. | |||||||||||||||||||||
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- [1]. Bisogno T, et al. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. The Biochemical journal. 2000 Nov 01;351 Pt 3(Pt 3):817-24. [Content Brief]
- [2]. Huang SM, et al. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proceedings of the National Academy of Sciences of the United States of America. 2002 Jun 11;99(12):8400-5. [Content Brief]
- [3]. Fawley JA, et al. Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Jun 11;34(24):8324-32. [Content Brief]
