755036-45-4
755036-45-4
Chemical Structure
Dichotomine C
Synonym(s): (R)-(-)-Dichotomine C
- CAS No.: 755036-45-4
- Formula:C15H14N2O4
- Molecular Weight:286.28
SMILES: OC[C@@H](C1=C2C(C3=CC=CC=C3N2)=CC(C(OC)=O)=N1)O
Biological Activity: Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC50 of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC50s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions[1].
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Dichotomine C | Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC50 of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC50s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions. | |||||||||||||||||||||
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