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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
SCFβ-TrCP complex
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "SCFβ-TrCP complex" in MCE Product Catalog:
Target:
Research Areas:
NRX-1933 is a molecular glue (molecular glue) that enhances the interaction between β-catenin and β-TrCP. NRX-1933 promotes the ubiquitination and subsequent degradation of mutant β-catenin. NRX-1933 can be applied to tumor research involving aberrant activation of the Wnt/β-catenin signaling pathway .
Target:
Research Areas:
NRX-103094 is a Molecular glue and β-catenin/β-TrCP interaction enhancer, with an EC50 of 62 nM for the binding of pSer33/S37A β-catenin peptide to recombinant β-TrCP/Skp1 complex. NRX-103094 shows selectivity for Ser37 phosphorylation-deficient β-catenin, and has no effect on wild-type doubly phosphorylated β-catenin or other β-TrCP substrates. NRX-103094 can be used in research related to colorectal cancer and ovarian endometrioid adenocarcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
