2763260-30-4
Chemical Structure
NRX-1933
- CAS No.: 2763260-30-4
- Formula:C14H9F3N6O2
- Molecular Weight:350.26
IUPAC Name: N-(9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl)-3-(difluoromethyl)-1-(methyl-13C-d3)-1H-pyrazole-1,2-15N2-4-carboxamide
InChIKey: IAVMZDPIQIVLOG-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(F)(F)F)NC1=O)NC2=CC=CC(C3=NNN=N3)=C2
Biological Activity: NRX-1933 is a molecular glue (molecular glue) that enhances the interaction between β-catenin and β-TrCP. NRX-1933 promotes the ubiquitination and subsequent degradation of mutant β-catenin. NRX-1933 can be applied to tumor research involving aberrant activation of the Wnt/β-catenin signaling pathway[1][2][3].
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NRX-1933 | 99.51% | NRX-1933 is a molecular glue (molecular glue) that enhances the interaction between β-catenin and β-TrCP. NRX-1933 promotes the ubiquitination and subsequent degradation of mutant β-catenin. NRX-1933 can be applied to tumor research involving aberrant activation of the Wnt/β-catenin signaling pathway. | ||||||||||||||||||||
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References
- [1]. Simonetta KR, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature communications. 2019 Mar 29;10(1):1402. [Content Brief]
- [2]. Hu Y, et al. Molecular glue degrader for tumor treatment. Frontiers in oncology. 2024;14:1512666. [Content Brief]
- [3]. Tsai JM, et al. Targeted protein degradation: from mechanisms to clinic. Nature reviews. Molecular cell biology. 2024 Sep;25(9):740-757.
