2763260-30-4
Chemical Structure
NRX-1933
- CAS No.: 2763260-30-4
- Formula:C14H9F3N6O2
- Molecular Weight:350.26
IUPAC Name: N-(9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl)-3-(difluoromethyl)-1-(methyl-13C-d3)-1H-pyrazole-1,2-15N2-4-carboxamide
InChIKey: IAVMZDPIQIVLOG-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(F)(F)F)NC1=O)NC2=CC=CC(C3=NNN=N3)=C2
Biological Activity: NRX-1933 is a type of molecular glue. NRX-1933 is a β-catenin:β-TrCP interaction enhancer for the development of small molecule degraders. NRX-1933 promotes the ubiquitination of mutated β-Catenin, leading to degradation. NRX-1933 can be applied to tumor research on abnormal activation of Wnt/β - catenin signaling pathway[1][2].
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NRX-1933 | 99.51% | NRX-1933 is a type of molecular glue. NRX-1933 is a β-catenin:β-TrCP interaction enhancer for the development of small molecule degraders. NRX-1933 promotes the ubiquitination of mutated β-Catenin, leading to degradation. NRX-1933 can be applied to tumor research on abnormal activation of Wnt/β - catenin signaling pathway. | ||||||||||||||||||||
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Keywords
