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STAT4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	STAT (5) Apoptosis (1) HDAC (1) JAK (1) NF-κB (1) p38 MAPK (1) PROTACs (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Targets Recommended: STAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173236

STAT4-IN-1	STAT	Metabolic Disease Inflammation/Immunology Cancer
STAT4-IN-1 is an inhibitor of *STAT4* with a K_i of 0.35 μM. STAT4-IN-1 is expected to be used in the research of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes .

HY-109854A

(R)-Lisofylline (R)-Lisophylline	STAT	Metabolic Disease Inflammation/Immunology
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC₅₀ of 0.6 μM and interrupts IL-12 signaling-mediated *STAT4* activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research .

HY-169360

SD-436	PROTACs STAT	Cancer
SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC₅₀: 0.5 μM), with IC₅₀ of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361); Blue: E3 ligase ligand (HY-43722); Black: linker (HY-147052) .

HY-N0204

Pulchinenoside A Anemoside A3	NF-κB p38 MAPK	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pulchinenoside A (Anemoside A3) is an orally active triterpenoid glycoside found in the root of Pulsatilla chinensis. Pulchinenoside A has amti-inflammation, antitumor, antidepressant, immunoregulatory and neuroprotective efrects. Pulchinenoside A activates NF-κB/MAPK signaling pathway. Pulchinenoside A can induce relaxing effect in rat renal arteries. Pulchinenoside A can be used for the researches of experimental autoimmune encephalomyelitis, breast cancer, depression and renovascular hypertension ^[4] .

HY-172946

SD-2301	PROTACs STAT	Cancer
SD-2301 is a selective STAT3 PROTAC degrader. SD-2301 induces *STAT3* degradation without affecting the protein levels of other STAT family members (STAT1, STAT2, STAT4, STAT5, STAT6). SD-2301 exerts anti-tumor effects in B16F10-bearing mice. SD-2301 can be used for the study of cancer. (Pink: STAT3 ligand (HY-172947), Blue: VHL Ligand (HY-172948), Black: Linker (HY-W577012), VHL ligand-linker conjugate (HY-172949)) .

HY-RS13891

STAT4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STAT4 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT4 Human Pre-designed siRNA Set A STAT4 Human Pre-designed siRNA Set A

HY-161464

Chlopynostat	HDAC Apoptosis	Cancer
Chlopynostat (Compound 6c) is a HDAC1 inhibitor with a IC₅₀ value of 67 nM. Chlopynostat reverses STAT4/p66Shc defects by inhibiting HDAC1-induced < b>Apoptosis .

HY-173357

TYD-68	PROTACs JAK STAT	Inflammation/Immunology
TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC₅₀ value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced *STAT4* and *STAT1* phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis. (Pink: Target protein ligand (HY-173359); Black: Linker (HY-W007732B); Blue: E3 ligase ligand (HY-14658); E3 ligase ligand + Linker (HY-173358)) .

HY-RS17148

Stat4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat4 Mouse Pre-designed siRNA Set A Stat4 Mouse Pre-designed siRNA Set A

HY-RS23597

Stat4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat4 Rat Pre-designed siRNA Set A Stat4 Rat Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L008

*JAK/STAT* Compound Library**	693 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 693 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

693 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 693 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Pulchinenoside A Anemoside A3	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Other Diseases Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Source Classification	NF-κB p38 MAPK
Pulchinenoside A (Anemoside A3) is an orally active triterpenoid glycoside found in the root of Pulsatilla chinensis. Pulchinenoside A has amti-inflammation, antitumor, antidepressant, immunoregulatory and neuroprotective efrects. Pulchinenoside A activates NF-κB/MAPK signaling pathway. Pulchinenoside A can induce relaxing effect in rat renal arteries. Pulchinenoside A can be used for the researches of experimental autoimmune encephalomyelitis, breast cancer, depression and renovascular hypertension ^[4] .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76664

	STAT4 Protein, Human (sf9, His) Signal transducer and activator of transcription 4; STAT4	Human	Sf9 insect cells
	The STAT4 protein is mainly expressed in hematopoietic cells and is critical for cell growth, differentiation and immune responses. It plays a key role in T helper 1 cell differentiation, interferon gamma production, and various neutrophil activities. STAT4 Protein, Human (sf9, His) is the recombinant human-derived STAT4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2) ICC/IF (1) IP (2) WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

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HY-P80903

	STAT4 Antibody (YA055) STAT4; Signal transducer and activator of transcription 4	WB, IHC-P, IP	Human
	STAT4 Antibody (YA055) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT4.

HY-P80903A

	STAT4 Antibody (YA055)(PBS only) STAT4; Signal transducer and activator of transcription 4	WB, IHC-P, ICC/IF, IP, FC	Human
	STAT4 Antibody (YA055) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT4.

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STAT4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
STAT4 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Stat4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Stat4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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