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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
STAT4
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "STAT4" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-173236
Target:
Research Areas:
STAT4-IN-1 is an inhibitor of STAT4 with a Ki of 0.35 μM. STAT4-IN-1 is expected to be used in the research of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes .
Synonyms: (R)-Lisophylline
Target:
Research Areas:
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 μM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research .
Cat. No.: HY-169360
CAS No.: 2497585-50-7
SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 μM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma .
Cat. No.: HY-172946
CAS No.: 3054116-24-1
SD-2301 is a selective STAT3 PROTAC degrader. SD-2301 induces STAT3 degradation without affecting the protein levels of other STAT family members (STAT1, STAT2, STAT4, STAT5, STAT6). SD-2301 exerts anti-tumor effects in B16F10-bearing mice. SD-2301 can be used for the study of cancer .
Cat. No.: HY-N0204
CAS No.: 129724-84-1
Synonyms: Anemoside A3
Cat. No.: HY-RS13891
Target:
Research Areas:
STAT4 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-173357
CAS No.: 3110703-72-2
Research Areas:
TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways.
TYD-68 can be used in the study of psoriasis .
Cat. No.: HY-RS17148
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Research Areas:
Stat4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23597
Target:
Research Areas:
Stat4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P76664
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Signal transducer and activator of transcription 4; STAT4
Species:
Source:
Cat. No.: HY-L008
712 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).
MCE provides 712 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.
Cat. No.: HY-150895
CAS No.: 2754428-37-8
Research Areas:
SI-191 is a STAT3 inhibitor and a target protein ligand. SI-191 inhibits the growth of cancer cells. SI-191 can be used in the research of acute leukemia and lymphoma. SI-191 can be used for the synthesis of PROTAC SD-91 (HY-150251) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
