76 Results for "

Skin wound

" in MedChemExpress (MCE) Product Catalog:
Products (76)

76 Results for "Skin wound" in MCE Product Catalog:

11
11 Publications Verification
Cat. No.: HY-15651
CAS No.: 848141-11-7
Purity:  99.87%
Synonyms: AZD9668
Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
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8
8 Cited Publications
Cat. No.: HY-B0277
CAS No.: 5536-17-4
Synonyms: Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine
Vidarabine (Ara-A) is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .
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8
8 Cited Publications
Cat. No.: HY-N6666
CAS No.: 24356-66-9
Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .
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5
5 Cited Publications
Cat. No.: HY-17505
CAS No.: 145040-37-5
Synonyms: TCV-116
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure .
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5
5 Cited Publications
Cat. No.: HY-P1290
CAS No.: 121932-06-7
Synonyms: PKI-(6-22)-amide
Target:  

PKA

Research Areas:  

Neurological Disease

PKA Inhibitor Fragment (6-22) amide is a highly potent and specific competitive inhibitor of PKA, with Ki values of 1.7 nM and 1.6 nM against human and bovine PKA catalytic subunits, respectively. The IC50 of PKA Inhibitor Fragment (6-22) amide targeting bovine PKA is 8.6 nM. PKA Inhibitor Fragment (6-22) amide effectively abolishes PKA activity in mouse brain and spinal cord, and exerts in vivo efficacy via intracerebroventricular administration. PKA Inhibitor Fragment (6-22) amide significantly reverses low-dose morphine analgesic tolerance in mice and blocks photoaffinity labeling of cAMP-dependent protein kinase. PKA Inhibitor Fragment (6-22) amide can be applied to research in fields related to the mechanism of morphine analgesic tolerance and skin wound healing .
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4
4 Cited Publications
Cat. No.: HY-B2170A
CAS No.: 70775-75-6
Target:  

Bacterial

Research Areas:  

Infection

Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.
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3
3 Cited Publications
Cat. No.: HY-119358
CAS No.: 6402-36-4
Purity:  99.85%
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis .
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2
2 Cited Publications
Cat. No.: HY-B1024
CAS No.: 16485-10-2
Synonyms: DL-Pantothenol; DL-Pantothenyl alcohol
DL-Panthenol (DL-Pantothenol) is a precursor of pantothenic acid. DL-Panthenol easily penetrates the skin and has effects of deep moisturizing, promoting wound healing and anti-inflammation. DL-Panthenol can also be used as a hair conditioner in cosmetics. DL-Panthenol has low acute toxicity, non-sensitizing property, and no significant genotoxicity or reproductive and developmental toxicity. DL-Panthenol can be applied to the research of cosmetics .
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1
1 Cited Publications
Cat. No.: HY-P0063
CAS No.: 89030-95-5
Synonyms: GHK-Cu
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .
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1
1 Cited Publications
Cat. No.: HY-N6929
CAS No.: 565-63-9
Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .
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Cat. No.: HY-N2551
CAS No.: 1115-84-0
Synonyms: S-Methylmethionine sulfonium chloride
Category:  

Plants Compositae

Target:  

Others

Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration .
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Cat. No.: HY-W127575
CAS No.: 747-90-0
Synonyms: delta-3,5-Cholestadiene
Cholesta-3,5-diene is an inflammatory modulator that targets immune cells such as neutrophils and accelerates wound healing by promoting neutrophil chemotaxis and fibroblast migration. Cholesta-3,5-diene enhances immune cell recruitment and extracellular matrix deposition by activating chemokine receptor-mediated signaling pathways such as PI3K/Akt. Cholesta-3,5-diene can be applied topically to wound repair and has potential therapeutic value in chronic ulcers or skin lesions .
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Cat. No.: HY-134508
CAS No.: 34435-05-7
Purity:  99.92%
C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer .
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Cat. No.: HY-Y0850U6
CAS No.: 9002-89-5
Synonyms: Polyvinyl alcohol (Mw 205000); Poly(Ethenol) (Mw 205000)
PVA (Polyvinyl alcohol) (Mw 205000) is a polyvinyl alcohol with a molecular weight of 205000, which is used as a biological additive. PVA (Mw 205000) can be cross-linked through physical or chemical methods to form hydrogels, and is widely applied in fields such as biomedicine, food packaging, textiles, papermaking, sensing, and electronic devices. After PVA enema, it has an improving effect on acute colitis induced by DSS (HY-116282C) in mice .
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Cat. No.: HY-W250721A
CAS No.: 9007-20-9
Synonyms: CBM 940
Carbomer 940 (CBM 940) is an acrylic polymer with high viscosity, good thermal stability and histocompatibility. Carbomer 940 serves as a transdermal drug delivery carrier and an external gel matrix. Carbomer 940 has no cytotoxicity, and it can also improve blood supply in the stasis zone of burns and promote wound repair. Carbomer 940 is applicable to pharmaceutical research .
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Cat. No.: HY-Y0850U3
CAS No.: 9002-89-5
Synonyms: Polyvinyl alcohol (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization); Poly(Ethenol) (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization)
PVA (Polyvinyl alcohol) (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) is a water-soluble, biodegradable, biocompatible and non-immunogenic polymer. PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) causes no irritation to rabbit eyes, no skin sensitization in guinea pigs, promotes the proliferation of human skin keratinocytes, and reduces the loss of corneal endothelial cells. The LD50 of PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) in rats and dogs is greater than 10 g/kg. PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) is hardly absorbed by the digestive system, causes no adverse effects upon long-term oral administration, and shows no mutagenicity or carcinogenicity. However, repeated intravenous or portal vein injection of PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) may induce pathological changes such as glomerular lesions, anemia, hypertension or liver fibrosis in rats or dogs. Crosslinked nanofibers prepared by modifying PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) can be used in studies related to wound dressings and other applications .
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Cat. No.: HY-B0614A
CAS No.: 13009-99-9
Target:  

Bacterial Fungal

Research Areas:  

Infection

Mafenide Acetate is a potent sulfonamide antimicrobial agent. Mafenide Acetate exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide Acetate also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide Acetate can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds .
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Cat. No.: HY-B0614B
CAS No.: 138-37-4
Target:  

Bacterial Fungal

Research Areas:  

Infection

Mafenide hydrochloride is a potent sulfonamide antimicrobial agent. Mafenide hydrochloride exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide hydrochloride also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide hydrochloride can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds .
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Cat. No.: HY-N1198
CAS No.: 23141-25-5
Strictosamide is a compound that can be isolated from Nauclea officinalis. Strictosamide has various activities such as anti-inflammatory, analgesic, anti-Plasmodium, antifungal, and promoting wound healing .
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Cat. No.: HY-N2589
CAS No.: 19416-87-6
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .
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