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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
TNP
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "TNP" in MCE Product Catalog:
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Research Areas:
TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization[1][2][3].
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TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.
Synonyms: TNP-2198
Rifasutenizol (TNP-2198) is a dual-targeted antibacterial agent that has a good antibacterial effect on Helicobacter pylori infection. Rifasutenizol can be used in the study of microaerophilic and anaerobic bacterial infections .
Cat. No.: HY-108667
CAS No.: 61368-63-6
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TNP-ATP triethylammonium is a P2X receptor antagonist with an IC50 of 0.010 μM for P2X3 and an IC50 of 0.062 μM for P2X2/3. TNP-ATP triethylammonium acts as an inhibitor of CheA autophosphorylation, with a Ki of 0.7 µM. TNP-ATP triethylammonium blocks the functional activation of P2X1-7 receptors. TNP-ATP triethylammonium attenuates hypoxia-induced IL-1β expression and release. TNP-ATP triethylammonium alleviates visceral pain, and improves hypoxia-induced cognitive impairment, insufficient myelination and neuroinflammation. Binding of TNP-ATP triethylammonium to CheA enhances the fluorescence of the TNP group. TNP-ATP triethylammonium can be used in studies related to visceral pain. NP-ATP triethylammonium can be used in studies related to hypoxia-induced insufficient myelination and cognitive decline .
Cat. No.: HY-111782
CAS No.: 26001-38-7
Synonyms: 8-Thioguanosine
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8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll .
Cat. No.: HY-135184
CAS No.: 922717-97-3
Synonyms: CBR-2092; TNP-2092
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Rifaquizinone (CBR-2092; TNP-2092) is a rifamycin-quinolone hybrid antibiotic. Rifaquizinone has an IC50 of 0.034 μM against wild-type Staphylococcus aureus DNA-dependent RNA polymerase. Rifaquizinone potently inhibits Staphylococcus aureus infection, with an MIC range of 0.008-0.5 μg/mL against 300 clinical isolates of staphylococci and streptococci. Rifaquizinone can be used in research related to persistent Staphylococcus aureus infections .
Cat. No.: HY-19095
CAS No.: 125991-51-7
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TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo .
Cat. No.: HY-137610A
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TNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50 = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors). TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50 = 100 and 62 nM, respectively). TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED50 = 6.35 µmol/kg) [1][2].
Cat. No.: HY-173530
Synonyms: 8-Bromo TNP-Guanosine 5'-triphosphate tetrasodium
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8-Bromo TNP-GTP (8-Bromo TNP-Guanosine 5'-triphosphate) tetrasodium is a fluorescent TNP-GTP analogue with a TNP fluorophore and a bromo group at the 8-position. 8-Bromo TNP-GTP tetrasodium can be used to analyze the binding activity of GTP-binding proteins (such as Ras and Gα subunits) .
Cat. No.: HY-173535
Synonyms: TNP-β-L-Guanosine 5'-triphosphate tetrasodium
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TNP-β-L-GTP (TNP-β-L-Guanosine 5'-triphosphate) tetrasodium is a fluorescent GTP mimetic that can be used to study the binding kinetics and affinity of GTP-binding proteins (such as G proteins and GTPases). TNP-β-L-GTP tetrasodium carries a TNP fluorophore, which changes fluorescence intensity upon protein binding, allowing for quantitative analysis .
Cat. No.: HY-173533
Synonyms: 2-Chloro TNP-Inosine 5'-triphosphate tetrasodium
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2-Chloro TNP-ITP (2-Chloro TNP-Inosine 5'-triphosphate) tetrasodium is an analog of Inosine-5'-triphosphate trisodium salt (HY-W013706) .
Cat. No.: HY-RS14857
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TNP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14858
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TNP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-101932R
CAS No.: 129298-91-5
Synonyms: AGM-1470 (Standard)
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TNP-470 (Standard) is the analytical standard of TNP-470 (HY-101932). This product is intended for research and analytical applications. TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.
Cat. No.: HY-137609A
Synonyms: TNP-Guanosine 5'-triphosphate tetrasodium
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
TNP-GTP tetrasodium is a fluorescently labeled GTP (HY-113225) derivative. TNP-GTP tetrasodium can inhibit glutamate dehydrogenase (Ki = 2.7 μM). TNP-GTP tetrasodium is an antagonist of the purinergic P2X2 and P2X2/3 receptors with IC50 values of 0.4 and 1.2 nM, respectively. TNP-GTP tetrasodium also inhibit rat soluble guanylyl cyclase (Ki = 11 nM) .
Cat. No.: HY-173532
Synonyms: 2-Methylthio TNP-Inosine 5'-triphosphate tetrasodium
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2-Methylthio TNP-ITP (2-Methylthio TNP-Inosine 5'-triphosphate) tetrasodium is a fluorescent derivative of inosine triphosphate (ITP) with a TNP (2,4,6-trinitrophenyl) fluorophore .
Cat. No.: HY-110079R
CAS No.: 519178-28-0
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TNP (Standard) is the analytical standard of TNP (HY-110079). This product is intended for research and analytical applications. TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization .
Cat. No.: HY-173531
Synonyms: 8-Bromo TNP-Inosine 5'-triphosphate tetrasodium
Target:
Research Areas:
8-Bromo TNP-ITP (8-Bromo TNP-Inosine 5'-triphosphate) tetrasodium is an analog of Inosine-5'-triphosphate trisodium salt (HY-W013706) .
Cat. No.: HY-111782R
CAS No.: 26001-38-7
Synonyms: 8-Thioguanosine (Standard)
Research Areas:
8-Mercaptoguanosine (Standard) is the analytical standard of 8-Mercaptoguanosine (HY-111782). This product is intended for research and analytical applications. 8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
