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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Trypanosoma congolense
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Trypanosoma congolense" in MCE Product Catalog:
Cat. No.: HY-W342283
CAS No.: 536-71-0
Target:
Parasite Angiotensin-converting Enzyme (ACE) Angiotensin Receptor p38 MAPK STAT NF-κB TNF Receptor 5-HT Receptor
Research Areas:
Diminazene is an antiparasitic agent widely used to treat parasitic diseases caused by hemoparasites (such as trypanosomes and babesia). Diminazene acts as an ACE2 activator and exerts cardiovascular protective effects by activating the ACE2/Ang-(1-7)/Mas receptor axis. By regulating gut microbiota-tryptophan metabolism, Diminazene inhibits the activation of core inflammatory signaling pathways including MAPK, STAT and NF-κB, increases central 5-HT levels, and suppresses splenic TNF-α production, thereby alleviating systemic inflammation .
Cat. No.: HY-145287
CAS No.: 1970223-53-0
Target:
Research Areas:
S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines .
Cat. No.: HY-143322
CAS No.: 1990479-17-8
CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis .
Cat. No.: HY-145287A
CAS No.: 1970223-54-1
Target:
Research Areas:
S-MGB-234 TFA is a minor groove binder used for African Animal Trypanosomiasis (AAT). S-MGB-234 exhibits excellent in vitro activity against the primary pathogens of AAT: Trypanosoma congolense and Trypanosoma vivax. S-MGB-234 TFA does not show cross-resistance with current diamidine active molecules and is not internalized via the transporters used by diamidines .
Cat. No.: HY-145812
CAS No.: 1990479-14-5
CRK12-IN-1 is a potent CRK12 inhibitor. CRK12-IN-1 is extremely potent against T.b. brucei and rapidly cytocidal, as well as equally potent against T. congolense and T. vivax (EC50 of 1.3 and 18 nM, respectively) .
Homidium chloride is a potent antiparasitic agent exhibiting activity against Trypanosoma rhodesiense and Trypanosoma congolense. Homidium chloride can reduce parasitaemia in murine models of infection. Homidium chloride can be used for trypanosomiasis research .
Cat. No.: HY-187603
CAS No.: 211816-91-0
CGP 40215 is an S-adenosylmethionine decarboxylase inhibitor with an IC50 of 20.3 μM against Trypanosoma brucei brucei AdoMet decarboxylase. CGP 40215 blocks spermidine production and leads to putrescine accumulation. CGP 40215 inhibits polyamine biosynthesis in intact trypanosomes, acts synergistically with the ornithine decarboxylase inhibitor DFMO (HY-B0744) against CNS model infections, and ameliorates laboratory infections caused by multiple Trypanosoma brucei subspecies and Trypanosoma congolense isolates, including strains tolerant to standard trypanocides. CGP 40215 can be used for research on African trypanosomiasis and Chagas disease .
Cat. No.: HY-184074
CAS No.: 2152662-88-7
Enfiborole is an oxaborolane ester inhibitor with trypanocidal activity against parasites. Enfiborole displays IC50 values ≤ 20 nM against Trypanosoma brucei and Trypanosoma cruzi, and its IC50 against replicating trypanosomes ranges from 21 to 999 nM. Enfiborole inhibits the growth of Trypanosoma brucei, suppresses hypoxanthine incorporation in replicating trypanosomes, and inhibits the growth of Trypanosoma cruzi amastigotes. Enfiborole can be used in studies related to trypanosome infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
