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Isoforms Recommended:	UCHL3

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UCH-L3

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標的別:	Apoptosis (1) Deubiquitinase (6) Small Interfering RNA (siRNA) (3)
研究分野別:	Cancer (4) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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製品番号	製品名	Target	研究分野	構造式

HY-18637

LDN-57444 Maximum Cited Publications 18 Publications Verification	Deubiquitinase Apoptosis	Neurological Disease
LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC₅₀ of 0.88 μM and a K_i of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC₅₀ of 25 μM.

HY-18638

TCID 5+ Cited Publications 4,5,6,7-Tetrachloroindan-1,3-dione	Deubiquitinase	Neurological Disease
TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC₅₀ of 0.6 μM . TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons .

HY-133118

6RK73 4 Publications Verification	Deubiquitinase	Cancer
6RK73 is a covalent irreversible and specific *UCHL1* inhibitor with an IC₅₀ of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC₅₀=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer .

HY-149230

USP28-IN-4	Deubiquitinase	Cancer
USP28-IN-4 is a USP28 inhibitor (IC₅₀=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

HY-RS15401

UCHL3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UCHL3 Human Pre-designed siRNA Set A contains three designed siRNAs for UCHL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UCHL3 Human Pre-designed siRNA Set A UCHL3 Human Pre-designed siRNA Set A

HY-RS17309

Uchl3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Uchl3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uchl3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Uchl3 Mouse Pre-designed siRNA Set A Uchl3 Mouse Pre-designed siRNA Set A

HY-RS23764

Uchl3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Uchl3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Uchl3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Uchl3 Rat Pre-designed siRNA Set A Uchl3 Rat Pre-designed siRNA Set A

HY-149229

USP28-IN-3	Deubiquitinase	Cancer
USP28-IN-3 is a USP28 inhibitor (IC₅₀=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

HY-149228

USP28-IN-2	Deubiquitinase	Cancer
USP28-IN-2 is a USP28 inhibitor (IC₅₀=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

組換えタンパク質 Recommended:

UCH-L3

Species:	Human (1) Rat (1) Mouse (1)
Tag:	His (3)
Source:	E. coli (3)

製品番号	Compare	製品名	Species	Source	Image

HY-P76119A

	UCHL3 Protein, Mouse (His, solution) UCH-L3; Ubiquitin thioesterase L3; UCHL3	Mouse	E. coli
	UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is involved in the regulation of cellular processes and protein degradation. It is particularly expressed in the testes and plays a vital role in spermatogenesis. UCHL3 Protein's significance in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine. UCHL3 Protein, Mouse (His, solution) is the recombinant mouse-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag.

HY-P71115

	UCHL3 Protein, Human (His) 1 Publications Verification Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3; UCH-L3; Ubiquitin Thioesterase L3; UCHL3	Human	E. coli
	UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is responsible for protein degradation and regulation of cellular processes. It is prominently expressed in the testes and plays a crucial role in spermatogenesis. UCHL3 Protein, Human (His) is the recombinant human-derived UCHL3 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P76689

	UCHL3 Protein, Rat (His) Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; Ubiquitin thioesterase L3	Rat	E. coli
	The UCHL3 protein is a deubiquitinating enzyme (DUB) that complexly controls cellular ubiquitin levels by processing ubiquitin precursors and ubiquitinated proteins. As a thiol protease, UCHL3 selectively recognizes and hydrolyzes the peptide bond of ubiquitin or the C-terminal glycine of NEDD8, showing a 10-fold preference for Arg and Lys at the P3 position, and has a special preference for "Lys-48" linked ubiquitin chains. affinity. UCHL3 Protein, Rat (His) is the recombinant rat-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (1) IF-Tissue (1) IHC-F (1) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P83066

	UCHL3 Antibody (YA2811) UCH-L3; Ubiquitin thiolesterase L3; Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCHL3	WB	Human, Mouse, Rat
	UCHL3 Antibody (YA2811) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UCHL3.

HY-P87636

	UCHL3 Antibody (YA7320)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	UCHL3 Antibody (YA7320) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UCHL3.

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製品番号	製品名		Classification

HY-RS15401

UCHL3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
UCHL3 Human Pre-designed siRNA Set A contains three designed siRNAs for UCHL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17309

Uchl3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Uchl3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uchl3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23764

Uchl3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Uchl3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Uchl3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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