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VH 101, thiol

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148030
    XL01126

    		PROTACs LRRK2 Neurological Disease
    XL01126 is a potent LRRK2 PROTAC (DC50: 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2)) composed of the VHL ligand VH 101, thiol (HY-47851, blue part) and the LRRK2 inhibitor HG-10-102-01 (HY-13488, red part). XL01126 crosses the blood-brain barrier and is used as a degradation probe in Parkinson's disease research. XL01126 can be used to study the non-catalytic and framework functions of LRRK2 .
    XL01126
  • HY-47851
    VH 101, thiol

    		Ligands for E3 Ligase Cancer
    VH 101, thiol (compound 20) is a VHL ligand for the synthesis of PROTACs .
    VH 101, thiol
  • HY-168448
    dBAZ2

    		PROTACs Epigenetic Reader Domain Cancer
    dBAZ2 is a first-in-class BAZ2A and BAZ2B PROTAC degrader with DC50 values of 180 nM and 250 nM for BAZ2A and BAZ2B, respectively. (Blue: E3 ligase ligand (VH 101, thiol (HY-47851); Black: linker (HY-168450); pink: target protein ligand (HY-168449)) .
    dBAZ2
  • HY-168451
    trans-VH 101-Thiol-C-cyclohexane-p-C-OTs

    		E3 Ligase Ligand-Linker Conjugates Cancer
    trans-VH 101-Thiol-C-cyclohexane-p-C-OTs is the conjugate of an ligand for E3 ligase ligand and a linker, that can be used for synthesis of PROTAC degrader dBAZ2 (HY-168448) .
    trans-VH 101-Thiol-C-cyclohexane-p-C-OTs
  • HY-181737
    E3 Ligase Ligand-linker Conjugate 225

    		E3 Ligase Ligand-Linker Conjugates Others
    E3 Ligase Ligand-linker Conjugate 225 is an E3 ligase ligand-linker conjugate used for the synthesis of PROTACs; it consists of the PEG-based linker Bis-Tos-PEG3 (HY-W013731) and the VHL-type E3 ubiquitin ligase ligand VH 101 thiol (HY-47851). E3 Ligase Ligand-linker Conjugate 225 can be further coupled with a target protein ligand—such as MT-4 (HY-128595)—to synthesize the PROTAC TG2 Degrader-3 (HY-181732) .
    E3 Ligase Ligand-linker Conjugate 225

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