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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
Valosin-containing protein
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "Valosin-containing protein" in MCE Product Catalog:
Target:
Research Areas:
KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress .
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases .
Cat. No.: HY-P705508
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: VCP; Valosin containing protein; Transitional Endoplasmic Reticulum ATPase; 15S Mg(2+)-ATPase P97 Subunit; Valosin-containing protein; CDC48; TERA; P97; TER ATPase; IBMPFD; Vesicle-Fusing ATPase; VCP protein; HEL-S-70; FTDALS6; HEL-220
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701435
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VCPIP1; Valosin containing protein Interacting protein 1; VCIP135; KIAA1850; DUBA3; Valosin-containing protein P97/P47 Complex-Interacting protein P135; Valosin-containing protein P97/P47 Complex-Interacting protein 1; VCP/P47 Complex-Interacting 135-KDa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701436
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VCPIP1; Valosin containing protein Interacting protein 1; VCIP135; KIAA1850; DUBA3; Valosin-containing protein P97/P47 Complex-Interacting protein P135; Valosin-containing protein P97/P47 Complex-Interacting protein 1; VCP/P47 Complex-Interacting 135-KDa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703170
Synonyms: NVL; Nuclear VCP-Like protein; Nuclear VCP Like; NVLp; NVL2; NVL protein; Nuclear Valosin-containing protein-Like
Species:
Human
Source:
E. coli
Cat. No.: HY-183257
CAS No.: 1242983-93-2
Research Areas:
ATI-1 is an autophagy initiation inhibitor. ATI-1 targets valosin-containing protein (VCP/p97, disrupts its interaction with UFL1, impairs UFMylation homeostasis associated with VCP, promotes polyubiquitination and degradation of Beclin1, and blocks the formation of early autophagosomes. ATI-1 induces synergistic death of autophagy-dependent malignant tumor cells under nutrient deprivation conditions, accompanied by decreased mitochondrial membrane potential, reduced ROS levels and lysosomal stress. ATI-1 exhibits anti-tumor efficacy in a pancreatic adenocarcinoma xenograft mouse model. ATI-1 can be used for the research of pancreatic adenocarcinoma and lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
