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Cat. No.: HY-168324

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UP158

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UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 2.57 μM.

For research use only. We do not sell to patients.

Purity: 99.88%
CAS No.: 489402-33-7
Formula: C₁₇H₁₇ClN₄O₂
Molecular Weight:344.80

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

UP158 Chemical Structure

CAS No.: 489402-33-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 2.57 μM^[1].

Chemical Information

CAS No. 489402-33-7
Appearance Solid
Molecular Weight 344.80
Formula C₁₇H₁₇ClN₄O₂
Color White to off-white
SMILES

ClC1=CC2=C(NC3=C(N4CCC5(CC4)OCCO5)N=CN=C32)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134(14):e169039. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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UP158

MCE Bioactive Compound Library