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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
antivirulence agent
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "antivirulence agent" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N0241
CAS No.: 85571-15-9
Cat. No.: HY-163542
CAS No.: 330842-49-4
Target:
Research Areas:
Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 µM). Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae .
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA) .
Cat. No.: HY-162496
CAS No.: 2159078-06-3
Target:
Research Areas:
L-NBDNJ, a glycomimetic, is an antivirulence agent. L-NBDNJ interferes with the expression of proteins regulating cytoskeleton assembly and organization of the host cell. L-NBDNJ has anti-inflammatory and anti-infective effects in models of cystic fibrosis (CF) lung disease infection .
Cat. No.: HY-161124
SrtA-IN-2 (compound Y40), a ML346 (HY-18669) analog, is a Sortase A (SrtA) inhibitor. SrtA-IN-2 shows inhibitory activity on Staphylococcus aureus SrtA and shows inhibitory effects on biofilm formation. SrtA-IN-2 is an antivirulence agent against S. aureus infections .
Cat. No.: HY-173428
Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections .
Cat. No.: HY-124469
CAS No.: 1799734-10-3
UM-C162, a benzimidazole derivative, can rescue nematodes from a S. aureus infection. UM-C162 prevents the formation of biofilm without interfering with bacterial viability. UM-C162 mediates the disruption of S. aureus hemolysins, proteases and clumping factors production. UM-C162 has the potential to be used as an anti-virulence agent to control S. aureus infections .
Cat. No.: HY-187556
CAS No.: 2581199-68-8
Antibiofilm agent-23 is a PqsR-targeting agent, iron chelator, biofilm inhibitor, biofilm dispersant, and anti-virulence agent. Antibiofilm agent-23 selectively binds to PqsR, disrupts the pqs quorum sensing pathway, restricts bacterial iron acquisition, induces intracellular iron deficiency, reduces pyocyanin, elastase, and rhamnolipid production, impairs biofilm formation, and disperses mature biofilms. Antibiofilm agent-23 exhibits low cytotoxicity and shows antibacterial synergy with Ciprofloxacin (HY-B0356) in Caenorhabditis elegans infection models. Antibiofilm agent-23 can be used for the research of biofilm-associated Pseudomonas aeruginosa infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
