Search Result

Results for "

anxiolytic effect

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (6) Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (1) Bcl-2 Family (1) Drug Derivative (1) Drug Metabolite (2) Endogenous Metabolite (2) Environmental Pollutants (1) Epigenetic Reader Domain (2) ERK (1) GABA Receptor (4) GnRH Receptor (1) Histamine Receptor (6) iGluR (1) Isotope-Labeled Compounds (1) mGluR (1) MMP (1) nAChR (2) Opioid Receptor (2) PAK (1) Parasite (3) PGC-1α (2) Reactive Oxygen Species (ROS) (1) Reference Standards (6)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Endocrinology (6) Infection (3) Inflammation/Immunology (10) Neurological Disease (33)

By Targets:

5-HT Receptor (6)

Aldehyde Dehydrogenase (ALDH) (1)

Apoptosis (1)

Bcl-2 Family (1)

Drug Derivative (1)

Drug Metabolite (2)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Epigenetic Reader Domain (2)

ERK (1)

GABA Receptor (4)

GnRH Receptor (1)

Histamine Receptor (6)

iGluR (1)

Isotope-Labeled Compounds (1)

mGluR (1)

MMP (1)

nAChR (2)

Opioid Receptor (2)

PAK (1)

Parasite (3)

PGC-1α (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (6)

By Research Areas:

Cancer (3)

Cardiovascular Disease (1)

Endocrinology (6)

Infection (3)

Inflammation/Immunology (10)

Neurological Disease (33)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19801

CVT-10216 3 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Neurological Disease
CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC₅₀ of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC₅₀ of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects .

HY-B0548

Hydroxyzine 1 Publications Verification	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .

HY-101105A

SB-224289 hydrochloride 2 Publications Verification SB-224289A	5-HT Receptor	Neurological Disease
SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.

HY-B0548A

Hydroxyzine dihydrochloride 1 Publications Verification	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-105042

Selank Selanc; TP-7	GABA Receptor	Neurological Disease
Selank (Selanc; TP-7) is a GABAA receptor modulator with anxiolytic activity. Selank allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank can be used in the research of anxiety disorders .

HY-P5762

Phoenixin-14 PNX-14	GnRH Receptor	Neurological Disease
Phoenixin-14 (PNX-14) is one of the endogenous active isoform, and generates anxiolytic effect via the activation of the AHA GnRH system in mice. Phoenixin-14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia .

HY-P5763

Phoenixin-20 PNX-20	Epigenetic Reader Domain PGC-1α	Neurological Disease
Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 has anxiolytic effect .

HY-19490

VQW-765 AQW-051	nAChR	Neurological Disease
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pK_D value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety .

HY-136591

Demoxepam	Drug Metabolite	Neurological Disease Cancer
Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects. Demoxepam has an inhibitory effect on in vitro [ ³H]tryptophan binding to rat hepatic nuclei .

HY-N8303

Gardenin A	ERK PAK	Neurological Disease Inflammation/Immunology
Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects .

HY-101725

Meclonazepam Ro 11-3128; Ro 11-3128/002	Parasite	Infection Neurological Disease
Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect . Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect .

HY-107722

SCH 221510	Opioid Receptor	Neurological Disease
SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC₅₀ of 12 nM and K_i of 0.3 nM. SCH 221510 shows an anxiolytic-like effect .

HY-19686

Ipsapirone TVX Q 7821 free base	5-HT Receptor	Neurological Disease
Ipsapirone (TVX Q 7821) is an anxiolytic compound and a 5-HT_1A receptor partial agonist. Ipsapirone (TVX Q 7821) also exhibits 5-HT_1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT₂ and the α₁-adrenergic function .

HY-141795

Posovolone Co 134444	Drug Derivative	Neurological Disease
Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects .

HY-123840

MRK-623	GABA Receptor	Neurological Disease
MRK-623 (Compound 14k) is an orally active, high-affinity GABA_A receptor agonist, with the K_i values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. MRK-623 shows anxiolytic effect .

HY-101105

SB-224289	5-HT Receptor	Neurological Disease
SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect .

HY-N5126

Juncusol	Others	Neurological Disease
Juncusol, a phenanthrenoid found in Juncus setchuenensis, possesses anxiolytic effect. Juncusol is associated with metabolic changes in cortical serotonin/dopamine levels in Mice .

HY-N10497

Dihydro-β-erythroidine	nAChR	Neurological Disease
Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced .

HY-B0548AS1

Hydroxyzine-d4' dihydrochloride Vistaril-d4' dihydrochloride; Atarax-d4' dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine-d₄ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-W150182

p-Cymen-8-ol	Environmental Pollutants	Neurological Disease Inflammation/Immunology
p-Cymen-8-ol is an alcohol. p-Cymen-8-ol can be used to make essential oils. Essential oils containing p-Cymen-8-ol exhibit immunomodulatory activity. p-Cymen-8-ol, when used in combination with other substances to make essential oils, exerts an anxiolytic-like effect and reduces hepatic lipid peroxidation levels in ICR mice. p-Cymen-8-ol may be used in research on anxiolytic and other neurological and immune system disorders .

HY-167825

Barakol	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects .

HY-107323

Bentazepam QM 6008; Thiadipone; Tiadipone	GABA Receptor	Neurological Disease
Bentazepam (Thiadipone) is a compound with short-action anxiolytic effect. Bentazepam shows anticonvulsant and sedative properties. Bentazepam can be used for the research of depressive disorder and anxiety .

HY-169445

(±)-Meclonazepam (±)-Ro 11-3128; (±)-Ro 11-3128/002	Parasite	Infection Neurological Disease
(±)-Meclonazepam ((±)-Ro 11-3128) is the racemate of Meclonazepam (HY-101725). Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect . Meclonazepam exhibits antischistosomal activity against S. mansoni .

HY-107323A

Bentazepam hydrochloride QM 6008 hydrochloride; Thiadipone hydrochloride; Tiadipone hydrochloride	GABA Receptor	Neurological Disease
Bentazepam (QM 6008, Thiadipone) hydrocholide is a compound with short-action anxiolytic effect. Bentazepam hydrocholide shows anticonvulsant and sedative properties. Bentazepam hydrocholide can be used for the research of depressive disorder and anxiety .

HY-117646

FG-5893	5-HT Receptor	Neurological Disease
FG-5893 is a 5-HT1A receptor agonist and a 5-HT2 receptor antagonist. FG-5893 has anxiolytic effect .

HY-144698

mGlu4 receptor agonist 1	mGluR	Neurological Disease
mGlu4 receptor agonist 1 (compound 62) is a potent mGlu4 receptor positive allosteric modulator, with an EC₅₀ of 308 nM. mGlu4 receptor agonist 1 shows significant anxiolytic- and antipsychotic-like effect .

HY-B0548AS2

Hydroxyzine-d8 dihydrochloride	Isotope-Labeled Compounds Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine-d₈ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-B0548R

Hydroxyzine (Standard)	Reference Standards Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine (Standard) is the analytical standard of Hydroxyzine. This product is intended for research and analytical applications. Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .

HY-19686A

Ipsapirone hydrochloride TVX Q 7821	5-HT Receptor	Neurological Disease
Ipsapirone hydrochloride (TVX Q 7821) is an anxiolytic compound and a 5-HT_1A receptor partial agonist. Ipsapirone hydrochloride (TVX Q 7821) also exhibits 5-HT_1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT₂ and the α₁-adrenergic function .

HY-B0548AR

Hydroxyzine dihydrochloride (Standard)	Reference Standards Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine (dihydrochloride) (Standard) is the analytical standard of Hydroxyzine (dihydrochloride). This product is intended for research and analytical applications. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-11084

SNAP-7941	Endogenous Metabolite	Neurological Disease
SNAP-7941 is a selective antagonist with anxiolytic, antidepressant and appetite suppressant activities. SNAP-7941 showed promising biological activity in initial animal studies. SNAP-7941 targets the melanin concentrating hormone receptor MCH1 and has significant inhibitory potential. SNAP-7941 was shown to inhibit the centrally induced MCH-induced drinking effect in in vivo studies .

HY-P5763A

Phoenixin-20 TFA PNX-20 TFA	Epigenetic Reader Domain PGC-1α	Neurological Disease
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 (TFA) promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 (TFA) has anxiolytic effect .

HY-115861

UCM765	Endogenous Metabolite	Neurological Disease
UCM765 is a selective MT2-type melatonin receptor ligand with hypnotic, analgesic and anxiolytic activities. The partial agonist effect of UCM765 has attracted attention in pharmacological studies. By structurally modifying UCM765, its water solubility and metabolic stability can be improved, thereby increasing its bioavailability. The biological activity of UCM765 has been verified in a rat model, supporting its potential for further pharmacological studies .

HY-101725R

Meclonazepam (Standard) Ro 11-3128 (Standard); Ro 11-3128/002 (Standard)	Reference Standards Parasite	Infection Neurological Disease
Meclonazepam (Standard) (Ro 11-3128 (Standard)) is the analytical standard of Meclonazepam (HY-101725). This product is intended for research and analytical applications. Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect . Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect .

HY-101105AR

SB-224289 hydrochloride (Standard) SB-224289A (Standard)	5-HT Receptor Reference Standards	Neurological Disease
SB-224289 (hydrochloride) (Standard) is the analytical standard of SB-224289 (hydrochloride) (HY-101105A). This product is intended for research and analytical applications. SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.

HY-107722R

SCH 221510 (Standard)	Reference Standards Opioid Receptor	Neurological Disease
SCH 221510 (Standard) is the analytical standard of SCH 221510 (HY-107722). This product is intended for research and analytical applications. SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC₅₀ of 12 nM and K_i of 0.3 nM. SCH 221510 shows an anxiolytic-like effect .

HY-136591R

Demoxepam (Standard)	Drug Metabolite Reference Standards	Neurological Disease Cancer
Demoxepam (Standard) is the analytical standard of Demoxepam. This product is intended for research and analytical applications. Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects. Demoxepam has an inhibitory effect on in vitro [ ³H]tryptophan binding to rat hepatic nuclei .

HY-15080

GYKI 53405 LY 293606	iGluR	Cardiovascular Disease Neurological Disease
GYKI 53405 is a non-competitive, orally active AMPA receptor antagonist. GYKI 53405 shows no significant binding affinity for GABA_A, GABA_B or benzodiazepine receptors. GYKI 53405 increases self-grooming behavior, induces wet dog-like shakes, reduces spontaneous activity, produces anxiolytic-like behavior, reverses the anxiogenic effect induced by mCPP, inhibits locomotor activity, suppresses sound-induced and maximal electroshock-induced seizures, prolongs survival in global cerebral ischemia models, and exhibits sustained anticonvulsant effects at doses below the sedation threshold. GYKI 53405 can be used in research related to absence epilepsy, anxiety disorders and global cerebral ischemia .

Cat. No.	Product Name	Target	Research Area

HY-P0046

Glycyl-L-histidyl-L-lysine 2 Publications Verification GHK; Tripeptide-1	Peptides	Neurological Disease Inflammation/Immunology
Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance .