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Cat. No.: HY-N5126

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Juncusol

Juncusol, a phenanthrenoid found in Juncus setchuenensis, possesses anxiolytic effect. Juncusol is associated with metabolic changes in cortical serotonin/dopamine levels in Mice.

For research use only. We do not sell to patients.

CAS No.: 62023-90-9
Formula: C₁₈H₁₈O₂
Molecular Weight:266.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Juncusol Chemical Structure

CAS No.: 62023-90-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Juncusol, a phenanthrenoid found in Juncus setchuenensis, possesses anxiolytic effect. Juncusol is associated with metabolic changes in cortical serotonin/dopamine levels in Mice^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	12.5 μg/mL Compound: 1a	In vitro cytotoxic activity against B-16 mouse melanoma (B-16) In vitro cytotoxic activity against B-16 mouse melanoma (B-16)	[PMID: 4045930]
HEK293	IC₅₀	6.5 μM Compound: 8	Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assay Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assay	[PMID: 30892891]
L1210	IC₅₀	13.8 μg/mL Compound: 1a	In vitro cytotoxic activity against L-1210 mouse lymphocytic leukemia cell culture (ATCC CCL-219) In vitro cytotoxic activity against L-1210 mouse lymphocytic leukemia cell culture (ATCC CCL-219)	[PMID: 4045930]
RAW264.7	IC₅₀	3.1 μM Compound: Juncusol	Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay	[PMID: 29280630]

Chemical Information

CAS No. 62023-90-9
Molecular Weight 266.33
Formula C₁₈H₁₈O₂
SMILES

OC(C(C)=C1CC2)=CC=C1C3=C2C=C(O)C(C)=C3C=C
Structure Classification
- Phenols
- Polyphenols
- Others
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu Sun, et al. Anxiolytic effect of a novel 9,10-dihydrophenanthrene, juncuenin H, is associated with metabolic changes in cortical serotonin/dopamine levels in mice. Fitoterapia. 2019 Apr;134:165-171. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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