Selank (Synonyms: Selanc; TP-7)

Name: Selank
Brand: MedChemExpress
SKU: HY-105042
Rating: 4.5 (1 reviews)

Cat. No.: HY-105042 Purity: 99.58%: Data Sheet
COA

SDS
Handling Instructions
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Selank is a GABAA receptor modulator with anxiolytic activity. Selank allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank can be used in the research of anxiety disorders.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Selank Chemical Structure

CAS No. : 129954-34-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Selank:

Selank diacetate In-stock

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Description

In Vivo

Selank (300 μg/kg; i.n.; once daily; 14 days) minimizes test-induced anxiety-related behavioral deterioration in non-stressed rats, with no statistically significant changes in measured anxiety or locomotor activity parameters relative to pre-treatment levels^[1].
Selank (300 μg/kg; i.n.; once daily; 14 days) significantly mitigates stress-induced anxiety-related behavioral deterioration in UCMS-exposed rats compared to saline-treated controls^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar rats (male, average weight 400 g)^[1]
Dosage:	300 μg/kg
Administration:	i.n.; once daily; 14 days
Result:	Decreased median time spent in open arms from 40.2 s to 12.2 s. Increased median time spent in closed arms from 124.9 s to 147.7 s. Decreased median number of hanging events from open arms from 7 to 5. Decreased median number of squares crossed minimally from 36 to 30. Maintained median number of rears at 9.5.

Animal Model:	Wistar rats (male, average weight 400 g, UCMS-induced anxiety)^[1]
Dosage:	300 μg/kg
Administration:	i.n.; once daily; 14 days (concurrent with UCMS exposure)
Result:	Decreased median time spent in open arms from 64.7 s (41.7-79.4 s IQR) to 15.5 s (7-26.6 s IQR). Increased median time spent in closed arms from 104.7 s to 139.9 s. Decreased median number of hanging events from open arms from 9 to 4.5. Decreased median number of squares crossed from 39 to 22. Decreased median number of rears from 6.5 to 5.5. Exhibited magnitude of anxiety indicator changes similar to non-stressed rats administered Selank, and significantly less severe than changes observed in UCMS-exposed rats administered saline.

Clinical Trial

Molecular Weight

751.87

Formula

C₃₃H₅₇N₁₁O₉

CAS No.

129954-34-3

Appearance

Solid

Color

White to off-white

Sequence

Thr-Lys-Pro-Arg-Pro-Gly-Pro

Sequence Shortening

TKPRPGP

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (66.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3300 mL	6.6501 mL	13.3002 mL
5 mM	0.2660 mL	1.3300 mL	2.6600 mL
10 mM	0.1330 mL	0.6650 mL	1.3300 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (275 KB) SDS (254 KB)

COA (251 KB) RP-HPLC (251 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Kasian A, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3300 mL	6.6501 mL	13.3002 mL	33.2504 mL
	5 mM	0.2660 mL	1.3300 mL	2.6600 mL	6.6501 mL
	10 mM	0.1330 mL	0.6650 mL	1.3300 mL	3.3250 mL
	15 mM	0.0887 mL	0.4433 mL	0.8867 mL	2.2167 mL
	20 mM	0.0665 mL	0.3325 mL	0.6650 mL	1.6625 mL
	25 mM	0.0532 mL	0.2660 mL	0.5320 mL	1.3300 mL
	30 mM	0.0443 mL	0.2217 mL	0.4433 mL	1.1083 mL
	40 mM	0.0333 mL	0.1663 mL	0.3325 mL	0.8313 mL
	50 mM	0.0266 mL	0.1330 mL	0.2660 mL	0.6650 mL
	60 mM	0.0222 mL	0.1108 mL	0.2217 mL	0.5542 mL

Selank Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Selank (Synonyms: Selanc; TP-7)

Customer Review

Other Forms of Selank:

Selank Related Antibodies

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Complete Stock Solution Preparation Table

Selank Related Classifications

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