963-39-3
963-39-3
Chemical Structure
Demoxepam
- No. CAS: 963-39-3
- Formula:C15H11ClN2O2
- Molecular Weight:286.71
IUPAC Name: 7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine 4-oxide
InChIKey: GGRWZBVSUZZMKS-UHFFFAOYSA-N
SMILES: O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3)=[N+]([O-])C1
Biological Activity: Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects. Demoxepam has an inhibitory effect on in vitro [3H]tryptophan binding to rat hepatic nuclei[1][2][3].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Demoxepam | 99.5% | Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects. Demoxepam has an inhibitory effect on in vitro [3H]tryptophan binding to rat hepatic nuclei. | ||||||||||||||||||||
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Demoxepam (Standard) | ≥98% | Demoxepam (Standard) is the analytical standard of Demoxepam. This product is intended for research and analytical applications. Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects. Demoxepam has an inhibitory effect on in vitro [3H]tryptophan binding to rat hepatic nuclei. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-1707173-Methylnordiazepam -
Similarity Score 0.74
HY-W098756Thionordiazepam -
Similarity Score 0.73
HY-106454RN-Desalkylflurazepam (Standard) -
Similarity Score 0.72
HY-W634748Desalkylgidazepam -
Similarity Score 0.71
HY-20874Deschlorodemethyldiazepam -
Similarity Score 0.69
HY-1316227-Aminoclonazepam -
Similarity Score 0.69
HY-131622S7-Aminoclonazepam-13C6 -
Similarity Score 0.68
HY-108470RRo5-3335 (Standard) -
Similarity Score 0.68
HY-105791Sulazepam -
Explore the MedChemAI to find more analogs
References
- [1]. Moustapha Ouédraogo, et al. In vitro cytotoxicity study of oxaziridines generated after chlordiazepoxide, demoxepam, and desmethylchlordiazepoxide UV irradiation. Drug Chem Toxicol. 2009;32(4):417-23. [Content Brief]
- [2]. Gregory G Sarris, et al. Demoxepam Derivatization and GC-MS Analysis Produces Erroneous Nordiazepam and Oxazepam Results. J Anal Toxicol. 2019 Jun 1;43(5):406-410. [Content Brief]
- [3]. Sidransky, H., et al., (1992). Inhibitory effect of demoxepam on tryptophan binding to rat hepatic nuclei. Biochemical medicine and metabolic biology, 47(3), 270–273. [Content Brief]
