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Results for "

aromatic nucleophilic substitution

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Fluorescent Dyes

2

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W093017
    4-Chloropyridine

    		Amine N-methyltransferase Others
    4-Chloropyridine is a NNMT (Nicotinamide N-methyltransferase) substrate and suicide inhibition-based protein labeling scaffold precursor.4-Chloropyridine undergoes NNMT-catalyzed pyridine nitrogen methylation to increase C4 electrophilicity, enabling aromatic nucleophilic substitution by NNMT cysteine C159 for covalent NNMT modification and inactivation.4-Chloropyridine can be used for the research of various cancers .
    4-Chloropyridine
  • HY-W007690
    Pyridin-4-ol

    		Drug Intermediate Others
    Pyridin-4-ol is a pyridinol and can be used as synthetic intermediate .
    Pyridin-4-ol
  • HY-148629
    GDC-0134

    		JNK Neurological Disease
    GDC-0134 (RG6000) is a modulator targeting dual leucine zipper kinase (DLK) that can cross the blood-brain barrier. By inhibiting the kinase activity of DLK, GDC-0134 blocks the activation of the downstream JNK signaling pathway, suppresses DLK-dependent retrograde signal transduction of axon-to-soma degeneration, and exerts neuroprotective activity. GDC-0134 reduces TDP-43 protein aggregation and decreases the degree of neuromuscular junction denervation in motor neurons. GDC-0134 can be used in the research of amyotrophic lateral sclerosis (ALS), Alzheimer's disease and other DLK-related neurodegenerative diseases .
    GDC-0134
  • HY-34054
    2,4-Dichloro-5-nitropyridine

    		Drug Intermediate Others
    2,4-Dichloro-5-nitropyridine is a pyridine derivative, which can be used as a precursor to synthesize polyfluorinated pyrrolidine derivatives [3][4].
    2,4-Dichloro-5-nitropyridine
  • HY-W025838
    4,5-Dimethylbenzene-1,2-diamine

    		Drug Intermediate Others
    4,5-Dimethylbenzene-1,2-diamine is a substitute for aromatic diamine compound. 4,5-Dimethylbenzene-1,2-diamine act as a bidentate nucleophilic reagent and participates in the palladium (II)-mediated isocyanate addition reaction to construct a diaminocarbene palladium complex with potential catalytic activity .
    4,5-Dimethylbenzene-1,2-diamine
  • HY-120188
    CC618

    		PPAR Others
    CC618 is a selective PPARβ/δ antagonist. CC618 covalently modifies conserved Cys249 in the PPARβ/δ ligand-binding pocket via nucleophilic aromatic substitution, converting its thiol moiety to a 5-trifluoromethyl-2-pyridylthioether .
    CC618
  • HY-206852
    PF-06445974 precursor

    		Drug Intermediate Phosphodiesterase (PDE) Neurological Disease
    PF-06445974 precursor (Compound 28) is a nitro precursor and synthetic intermediate. PF-06445974 precursor can be used for the synthesis of PF-06445974 (HY-119190). PF-06445974 is a positron emission tomography (PET) compound that acts potently on PDE4B .
    PF-06445974 precursor
  • HY-158616
    4-Methyl-7-(2-nitrophenoxy)-2H-chromen-2-one

    		Fluorescent Dye Others
    4-Methyl-7-(2-nitrophenoxy)-2H-chromen-2-one (compound 2f) is a selenol fluorescent probe designed based on a nucleophilic aromatic substitution mechanism. It can selectively recognize selenols in neutral aqueous solution without significant interference from biological thiols, amines or alcohols. It can be used to quantify the selenium content in selenoenzymes and to image the activity of endogenous selenols in living cells.
    4-Methyl-7-(2-nitrophenoxy)-2H-chromen-2-one

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