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Cat. No.: HY-187359

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SR-B-182

SR-B-182 is a SARS-CoV-2 main protease (M_Pro) inhibitor with an IC₅₀ of 0.015 μM. SR-B-182 can be used for the research of COVID-19.

For research use only. We do not sell to patients.

Formula: C₉H₅N₅O₃
Molecular Weight:231.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR-B-182 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

SR-B-182 is a SARS-CoV-2 main protease (M_Pro) inhibitor with an IC₅₀ of 0.015 μM. SR-B-182 can be used for the research of COVID-19^[1].

In Vitro

SR-B-182 acts via a covalent mechanism based on nucleophilic aromatic substitution (SNAr), forming a covalent adduct with Cys145 at the catalytic site of MPro without causing steric hindrance conflict with the aa187-189 loop of MPro.^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 231.17
Formula C₉H₅N₅O₃
SMILES

O=[N+](C1=NON=C1C2=NC3=CC=CC=C3N2)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sandeep Atla, et al. High-Throughput Screening Identifies Covalent Inhibitors with Unique Chemistry and Binding Modes for SARS-CoV-2 Main Protease. JACS Au 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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