SR-B-182
SR-B-182 is a SARS-CoV-2 main protease (MPro) inhibitor with an IC50 of 0.015 μM. SR-B-182 can be used for the research of COVID-19.
For research use only. We do not sell to patients.
- Formula: C9H5N5O3
- Molecular Weight:231.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
SR-B-182 acts via a covalent mechanism based on nucleophilic aromatic substitution (SNAr), forming a covalent adduct with Cys145 at the catalytic site of MPro without causing steric hindrance conflict with the aa187-189 loop of MPro.[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 231.17
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Formula C9H5N5O3
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SMILES
O=[N+](C1=NON=C1C2=NC3=CC=CC=C3N2)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SR-B-182 Related Classifications
HY-187359 Related Classifications
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