45 Results for "

artemisinin

" in MedChemExpress (MCE) Product Catalog:
Products (45)

45 Results for "artemisinin" in MCE Product Catalog:

34
34 Publications Verification
Cat. No.: HY-B0094
CAS No.: 63968-64-9
Synonyms: Qinghaosu; NSC 369397
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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4
4 Cited Publications
Cat. No.: HY-122550
CAS No.: 101020-89-7
Purity:  99.93%
Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability .
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3
3 Cited Publications
Cat. No.: HY-N1457
CAS No.: 603-56-5
Chrysosplenetin is an orally active polymethoxyflavone. Chrysosplenetin exerts anticancer effects by inhibiting topoisomerase, protecting DNA and inducing apoptosis. Chrysosplenetin acts as an antimalarial sensitizer, reverses Artemisinin (HY-B0094) resistance by inhibiting and downregulating P-glycoprotein, and enhances the efficacy of Artemisinin. Chrysosplenetin promotes bone formation by activating the Wnt/β-catenin pathway and exerts anti-osteoporotic effects .
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2
2 Cited Publications
Cat. No.: HY-16762
CAS No.: 1029939-86-3
Synonyms: OZ439
Research Areas:  

Infection

Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2 .
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1
1 Cited Publications
Cat. No.: HY-B1896B
CAS No.: 915967-82-7
Target:  

Parasite

Research Areas:  

Infection

Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin .
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1
1 Cited Publications
Cat. No.: HY-B1896A
CAS No.: 85547-56-4
Target:  

Parasite

Research Areas:  

Infection

Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin .
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1
1 Cited Publications
Cat. No.: HY-149428
CAS No.: 2918262-09-4
Purity:  98.01%
Target:  

PROTACs

Research Areas:  

Cancer

AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .
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1
1 Cited Publications
Cat. No.: HY-111817
CAS No.: 1984890-99-4
Purity:  96.45%
Target:  

Parasite

Research Areas:  

Infection

ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial .
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1
1 Cited Publications
Cat. No.: HY-W585869
CAS No.: 92692-39-2
Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast .
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Cat. No.: HY-N1984
CAS No.: 80286-58-4
Synonyms: Qing Hao acid; Artemisinic acid; Arteannuic acid
Artemisinic acid (Qing Hao acid) is a sesquiterpene that can be isolated from Artemisia annua L. Artemisinic acid is also an important precursor for the synthesis of Artemisinin (HY-B0094). Artemisinic acid has various pharmacological activities, such as antimalarial activity, antitumor activity, antipyretic effect, antibacterial activity, allelopathic effect, and anti-adipogenic effect .
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Cat. No.: HY-B0094R
CAS No.: 63968-64-9
Synonyms: Qinghaosu (Standard); NSC 369397 (Standard)
Artemisinin (Standard) is the analytical standard of Artemisinin. This product is intended for research and analytical applications. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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Cat. No.: HY-137553
CAS No.: 133162-24-0
Purity:  99.29%
Synonyms: SM934 free base
Research Areas:  

Inflammation/Immunology

β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases .
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Cat. No.: HY-N4106
CAS No.: 85031-59-0
Synonyms: Dihydroqinghao acid
Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin (HY-B0094) .
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Cat. No.: HY-N1667
CAS No.: 3602-54-8
2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone from Artemisia annua. Artemisia annua is an analog of Artemisinin that is effective in the research of malaria .
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Cat. No.: HY-W129233
CAS No.: 131175-87-6
Synonyms: Dihydroartemisinin (α,β mixture)
Research Areas:  

Infection Cancer

Dihydroartemisinin (mixture of α and β isomers) is an anti-malaria and anticancer agent, as well as an active metabolite of artemisinin and its derivatives. Dihydroartemisinin exerts anticancer effects through various molecular mechanisms, such as inhibiting proliferation, inducing apoptosis, inhibiting tumor metastasis and angiogenesis, promoting immune function, inducing autophagy and endoplasmic reticulum stress .
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Cat. No.: HY-135578
CAS No.: 120020-26-0
Purity:  99.96%
Target:  

Parasite

Research Areas:  

Infection

Artelinic acid, a derivative of Artemisinin, is an antimalarial agent for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes .
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Cat. No.: HY-N9551
CAS No.: 14917-41-0
Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC50=0.043 μM), aromatase/CYP19A1 (IC50=2.8 μM), PTPase 1B (IC50=1.26 μM), and COX (IC50=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases .
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Cat. No.: HY-B0094S
CAS No.: 176652-07-6
Synonyms: Qinghaosu-d3; NSC 369397-d3
Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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Cat. No.: HY-W587751
CAS No.: 125184-95-4
Synonyms: Amorpha-4,11-diene-12-ol
Target:  

Drug Intermediate

Research Areas:  

Infection

Arteannuic alcohol (Amorpha-4,11-diene-12-ol) is a precursor substance in the biosynthetic pathway of Artemisinin (HY-B0094). Alcohol dehydrogenase catalyzes the dehydrogenation reaction of chlorogenic alcohol to produce artemisinic aldehyde .
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Cat. No.: HY-175498
Target:  

SARS-CoV

Research Areas:  

Infection

RLA-3107 is an artemisinin regioisomer that blocks ion channels, thereby preventing cations from entering the host cytoplasm. RLA-3107 is also a viroporin inhibitor .
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