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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
bile salt hydrolase
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "bile salt hydrolase" in MCE Product Catalog:
7
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice .
3
3 Cited Publications
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively .
1
Cat. No.: HY-N7761
CAS No.: 126979-84-8
Synonyms: Tetrahydro tanshinone I
Trijuganone B (Tetrahydro tanshinone I) is a naturally occurring covalent pan-inhibitor of gut microbial bile salt hydrolases that can be isolated from Salvia trijuga. Trijuganone B inhibits total gut microbial bile salt hydrolase activity in live microorganisms and murine gut luminal content. Trijuganone B can be used for the research of bile-acid-related metabolic disorders .
Cat. No.: HY-P2958
CAS No.: 37289-07-9
Synonyms: bile salt hydrolase
Target:
Research Areas:
Choloylglycine hydrolase (Bile salt hydrolase) is an important intestinal hydrolase. Choloylglycine hydrolase not only catalyzes the decomposition of conjugated bile acids into free bile acids and amino acids, but also exhibits amine N-acyltransferase activity, which re-links amino acids/amines to free bile acids (even conjugated bile acids) to produce bacterial bile acid amides. Choloylglycine hydrolase regulates the composition of the bile acid pool, intestinal mucosal barrier integrity, intestinal inflammatory responses, intestinal flora composition, host weight gain, circadian rhythm, and colonization resistance to Clostridioides difficile. Choloylglycine hydrolase can be used in the research of inflammatory bowel diseases, including ulcerative colitis and Crohn's disease .
Cat. No.: HY-145147A
AAA-10 formic is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH, respectively .
Cat. No.: HY-P74352
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CEL; Carboxyl Ester Lipase (bile salt-Stimulated Lipase); Carboxyl Ester Lipase; Fetoacinar Pancreatic Protein; BSSL; Lysophospholipase, Pancreatic; MODY8; Pancreatic Lysophospholipase; bile salt-Stimulated Lipase; Carboxyl Ester hydrolase; bile salt-Acti
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-E70124D
Target:
Research Areas:
Esterase, Schizophyllum commune Cholesterol (EC 3.1.1.13) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. Esterase participates in bile acid biosynthesis.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
